Support for this work was provided by grants from the National Institute of Aging (AG07232 and AG07702), the Charles S. Robertson Memorial Gift for research on Alzheimer's disease, the Blanchette Hooker Rockefeller Foundation, and the New York City Council Speaker's fund for Public Health Research.
Alcohol Intake and Risk of Dementia
Article first published online: 30 MAR 2004
Journal of the American Geriatrics Society
Volume 52, Issue 4, pages 540–546, April 2004
How to Cite
Luchsinger, J. A., Tang, M.-X., Siddiqui, M., Shea, S. and Mayeux, R. (2004), Alcohol Intake and Risk of Dementia. Journal of the American Geriatrics Society, 52: 540–546. doi: 10.1111/j.1532-5415.2004.52159.x
- Issue published online: 30 MAR 2004
- Article first published online: 30 MAR 2004
Objectives: To examine the association between intake of alcoholic beverages and risk of Alzheimer's disease (AD) and dementia associated with stroke (DAS) in a cohort of elderly persons from New York City.
Design: Cohort study.
Setting: The Washington Heights Inwood–Columbia Aging Project.
Participants: Nine hundred eighty community-dwelling individuals aged 65 and older without dementia at baseline and with data on alcohol intake recruited between 1991 and 1996 and followed annually.
Measurements: Intake of alcohol was measured using a semiquantitative food frequency questionnaire at baseline. Subjects were followed annually, and incident dementia was diagnosed using Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, criteria and classified as AD or DAS.
Results: After 4 years of follow-up, 260 individuals developed dementia (199 AD, 61 DAS). After adjusting for age, sex, apolipoprotein E (APOE)-ɛ4 status, education, and other alcoholic beverages, only intake of up to three daily servings of wine was associated with a lower risk of AD (hazard ratio=0.55, 95% confidence interval=0.34–0.89). Intake of liquor, beer, and total alcohol was not associated with a lower risk of AD. Stratified analyses by the APOE-ɛ4 allele revealed that the association between wine consumption and lower risk of AD was confined to individuals without the APOE-ɛ4 allele.
Conclusion: Consumption of up to three servings of wine daily is associated with a lower risk of AD in elderly individuals without the APOEε-4 allele.