The study was supported by the Sigrid Juselius Foundation, Helsinki University Research Funding, Ray (Finland's Slot Machine Association), the Ministry of Education, and the Research Council for Health of the Academy of Finland.
Genetic Variant of Lactase-Persistent C/T-13910 Is Associated with Bone Fractures in Very Old Age
Article first published online: 22 DEC 2004
Journal of the American Geriatrics Society
Volume 53, Issue 1, pages 79–82, January 2005
How to Cite
Enattah, N. S., Sulkava, R., Halonen, P., Kontula, K. and Järvelä, I. (2005), Genetic Variant of Lactase-Persistent C/T-13910 Is Associated with Bone Fractures in Very Old Age. Journal of the American Geriatrics Society, 53: 79–82. doi: 10.1111/j.1532-5415.2005.53014.x
- Issue published online: 22 DEC 2004
- Article first published online: 22 DEC 2004
- adult-type hypolactasia;
- single-nucleotide polymorphism (SNP);
- bone fractures;
- elderly people
Objectives: To determine the relation between the C/T-13910 single-nucleotide polymorphism residing 13,910 base pairs from the 5′ end of the lactase gene associated with lactase persistence and the occurrence of bone fractures in elderly people.
Design: Population-based study.
Setting: Vantaa 85+ population-based study, including all 601 subjects born before April 1, 1906, who were living in the city of Vantaa, Finland, on April 1, 1991.
Participants: Four hundred eighty-three people aged 85 and older (106 men and 377 women).
Measurements: Genotype determination was made using a polymerase chain reaction minisequencing technique.
Results: The frequency of the genotype C/C-13910 associated with adult-type hypolactasia (low lactase enzyme activity or primary lactose malabsorption (LM)) was significantly greater in individuals with hip fractures, with an adjusted odds ratio (OR) of 3.7 (95% confidence interval (CI)=1.8–7.8), wrist fractures with an adjusted OR of 2.5 (95% CI=1.2–5.2), and hip and wrist fractures combined with an adjusted OR of 4.1 (95% CI=2.0–8.3).
Conclusion: The C/C-13910 genotype associated with primary LM could represent a genetic risk factor for bone fractures for elderly people.