Funded by National Institute on Aging (NIA) Grants RO1 AG11703 and R37 AG019905; National Institutes of Health, National Center for Research Resources, Outpatient Department—General Clinical Research Center Grants RR00722, RO1 A141956; and NIA Contract NO1-AG12112.
Chronic Cytomegalovirus Infection and Inflammation Are Associated with Prevalent Frailty in Community-Dwelling Older Women
Article first published online: 18 MAR 2005
Journal of the American Geriatrics Society
Volume 53, Issue 5, pages 747–754, May 2005
How to Cite
Schmaltz, H. N., Fried, L. P., Xue, Q.-L., Walston, J., Leng, S. X. and Semba, R. D. (2005), Chronic Cytomegalovirus Infection and Inflammation Are Associated with Prevalent Frailty in Community-Dwelling Older Women. Journal of the American Geriatrics Society, 53: 747–754. doi: 10.1111/j.1532-5415.2005.53250.x
- Issue published online: 4 MAY 2005
- Article first published online: 18 MAR 2005
Objectives: To evaluate the association between asymptomatic chronic cytomegalovirus (CMV) infection and the frailty syndrome and to assess whether inflammation modifies this association.
Design: Cross-sectional analysis.
Setting: Women's Health and Aging Study I & II, Baltimore, Maryland.
Participants: Seven hundred twenty-four community-dwelling women aged 70 to 79 with baseline measures of CMV, interleukin-6 (IL-6), and frailty status.
Measurements: CMV serology and IL-6 concentrations were measured using enzyme-linked immunosorbent assay. Frailty status was based on previously validated criteria: unintentional weight loss, weak grip strength, exhaustion, slow walking speed, and low level of activity. Frail women had three or more of the five components, prefrail women had one or two components, and women who were not frail had none of the components. Multinomial logistic regression adjusted for potential confounders.
Results: Eighty-seven percent of women were CMV seropositive, an indication of chronic infection. CMV was associated with prevalent frailty, adjusting for age, smoking history, elevated body mass index, diabetes mellitus, and congestive heart failure (CMV frail adjusted odds ratio (AOR)=3.2, P=.03; CMV prefrail AOR=1.5, P=.18). IL-6 interacted with CMV, significantly increasing the magnitude of this association (CMV positive and low IL-6 frail AOR=1.5, P=.53; CMV positive and high IL-6 frail AOR=20.3, P=.007; CMV positive and low IL-6 prefrail AOR=0.9, P=.73; CMV positive and high IL-6 prefrail AOR=5.5, P=.001).
Conclusion: Chronic CMV infection is associated with prevalent frailty, a state with increased morbidity and mortality in older adults; inflammation enhances this effect. Further prospective studies are needed to establish a causal relationship between CMV, inflammation, and frailty.