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Keywords:

  • nocturia;
  • behavioral training;
  • drug therapy;
  • aged;
  • biofeedback;
  • urinary incontinence

Objectives: To examine changes in nocturia from a multicomponent behavioral training program or drug therapy in older women with urge or mixed (urge-predominant) urinary incontinence.

Design: A secondary analysis of data from a prospective, randomized clinical trial.

Setting: Parent trial was an outpatient research protocol in Alabama.

Participants: One hundred ninety-seven women (aged 55–92) with incontinence and urodynamic evidence of bladder dysfunction. At baseline, 131 women (66% of participants) had nocturia.

Intervention: In the parent study, participants received behavioral training, including four sessions of biofeedback-assisted pelvic floor muscle exercises, drug treatment (oxybutynin IR titrated from 2.5 mg per day to 5.0 mg three times a day), or placebo.

Measurements: Participant-completed bladder diaries were used to calculate changes in nocturia.

Results: Behavioral training reduced nocturia by a median 0.50 episodes per night and was significantly more effective than drug treatment (median reduction=0.30 episodes; P=.02) and placebo (median reduction=0.00 episodes; P<.001). Also, drug treatment was more effective than control (P=.007).

Conclusion: Both behavioral training and drug treatment reduced nocturia more than placebo, but behavioral training was the most effective.