This research was supported by a grant from the National Institute on Aging (AG RO108010). Dr. Johnson received additional support from the Emory University Center for Health in Aging. This paper was presented in abstract form at the American Geriatrics Society Meeting, Las Vegas, Nevada, May 20, 2004.
Effects of Behavioral and Drug Therapy on Nocturia in Older Incontinent Women
Version of Record online: 2 MAR 2005
Journal of the American Geriatrics Society
Volume 53, Issue 5, pages 846–850, May 2005
How to Cite
Johnson, T. M., Burgio, K. L., Redden, D. T., Wright, K. C. and Goode, P. S. (2005), Effects of Behavioral and Drug Therapy on Nocturia in Older Incontinent Women. Journal of the American Geriatrics Society, 53: 846–850. doi: 10.1111/j.1532-5415.2005.53260.x
- Issue online: 4 MAY 2005
- Version of Record online: 2 MAR 2005
- behavioral training;
- drug therapy;
- urinary incontinence
Objectives: To examine changes in nocturia from a multicomponent behavioral training program or drug therapy in older women with urge or mixed (urge-predominant) urinary incontinence.
Design: A secondary analysis of data from a prospective, randomized clinical trial.
Setting: Parent trial was an outpatient research protocol in Alabama.
Participants: One hundred ninety-seven women (aged 55–92) with incontinence and urodynamic evidence of bladder dysfunction. At baseline, 131 women (66% of participants) had nocturia.
Intervention: In the parent study, participants received behavioral training, including four sessions of biofeedback-assisted pelvic floor muscle exercises, drug treatment (oxybutynin IR titrated from 2.5 mg per day to 5.0 mg three times a day), or placebo.
Measurements: Participant-completed bladder diaries were used to calculate changes in nocturia.
Results: Behavioral training reduced nocturia by a median 0.50 episodes per night and was significantly more effective than drug treatment (median reduction=0.30 episodes; P=.02) and placebo (median reduction=0.00 episodes; P<.001). Also, drug treatment was more effective than control (P=.007).
Conclusion: Both behavioral training and drug treatment reduced nocturia more than placebo, but behavioral training was the most effective.