National Institute of Arthritis and Musculoskeletal and Skin Diseases, the National Institute on Aging, and the National Cancer Institute provided funding under the following grant numbers: U01 AR45580, U01 AR45614, U01 AR45632, U01 AR45647, U01 AR45654, U01 AR45583, U01 AG18197, and M01 RR000334.
Association Between Parkinson's Disease and Low Bone Density and Falls in Older Men: The Osteoporotic Fractures in Men Study
Article first published online: 23 JUN 2005
Journal of the American Geriatrics Society
Volume 53, Issue 9, pages 1559–1564, September 2005
How to Cite
Fink, H. A., Kuskowski, M. A., Orwoll, E. S., Cauley, J. A., Ensrud, K. E. and for the Osteoporotic Fractures in Men (MrOS) Study Group (2005), Association Between Parkinson's Disease and Low Bone Density and Falls in Older Men: The Osteoporotic Fractures in Men Study. Journal of the American Geriatrics Society, 53: 1559–1564. doi: 10.1111/j.1532-5415.2005.53464.x
A portion of the data in this manuscript was presented as a poster at the 2001 meeting of the American Society of Bone and Mineral Research.
- Issue published online: 1 SEP 2005
- Article first published online: 23 JUN 2005
- Parkinson's disease;
- bone density;
- accidental falls
Objectives: To examine the association between Parkinson's disease (PD) and bone mineral density (BMD) and risk of falls.
Design: Cross-sectional and prospective cohort study.
Setting: Six U.S. clinical centers.
Participants: Five thousand nine hundred ninety-five community-dwelling, ambulatory men aged 65 and older.
Measurements: History of physician-diagnosed PD was ascertained from participant self-report. BMD was measured at the hip and spine using dual energy x-ray absorptiometry (DEXA) and quantitative computed tomography (QCT). Incident falls were ascertained for 1 year using mailed queries.
Results: Fifty-two participants (0.9%) reported a history of PD. In multivariate models, PD was associated with significantly lower BMD at the spine (−4.9%, P=.04) and total hip (−5.3%, P=.007) using DEXA and at the spine (−6.7%, P=.05) and total hip (−8.2%, P=.03) using QCT. PD was associated with a nearly three times greater age-adjusted risk of multiple future falls (odds ratio (OR)=2.91, 95% confidence interval (CI)=1.55–5.46). Further adjustment for history of multiple falls in the year before baseline attenuated this risk, but it remained significant (OR=2.30, 95% CI=1.15–4.59).
Conclusion: In this cohort of older men, PD was associated with lower BMD at the hip and spine, measured using areal and volumetric BMD, as well as increased falls. Clinicians should consider screening older men with PD for osteoporosis.