Presented as a poster session at the 2006 Annual Scientific Meeting of the American Geriatrics Society.
Adverse Drug Events Resulting from Patient Errors in Older Adults
Version of Record online: 18 JAN 2007
Journal of the American Geriatrics Society
Volume 55, Issue 2, pages 271–276, February 2007
How to Cite
Field, T. S., Mazor, K. M., Briesacher, B., DeBellis, K. R. and Gurwitz, J. H. (2007), Adverse Drug Events Resulting from Patient Errors in Older Adults. Journal of the American Geriatrics Society, 55: 271–276. doi: 10.1111/j.1532-5415.2007.01047.x
- Issue online: 18 JAN 2007
- Version of Record online: 18 JAN 2007
- patient safety;
- adverse drug events;
- medication errors
OBJECTIVES: To characterize the types of patient-related errors that lead to adverse drug events (ADEs) and identify patients at high risk of such errors.
DESIGN: A subanalysis within a cohort study of Medicare enrollees.
SETTING: A large multispecialty group practice.
PARTICIPANTS: Thirty thousand Medicare enrollees followed over a 12-month period.
MEASUREMENTS: Primary outcomes were ADEs, defined as injuries due to a medication, and potential ADEs, defined as medication errors with the potential to cause an injury. The subset of these events that were related to patient errors was identified.
RESULTS: The majority of patient errors leading to adverse events (n=129) occurred in administering the medication (31.8%), modifying the medication regimen (41.9%), or not following clinical advice about medication use (21.7%). Patient-related errors most often involved hypoglycemic medications (28.7%), cardiovascular medications (21.7%), anticoagulants (18.6%), or diuretics (10.1%). Patients with medication errors did not differ from a comparison group in age or sex but were taking more regularly scheduled medications (compared with 0–2 medications, odds ratio (OR) for 3–4 medications=2.0, 95% confidence interval (CI)=0.9–4.2; OR for 5–6 medications=3.1, 95% CI=1.5–7.0; OR for ≥7 medications=3.3, 95% CI=1.5–7.0). The strongest association was with the Charlson Comorbidity Index (compared with a score of 0, OR for a score of 1–2=3.8, 95% CI=2.1–7.0; OR for a score of 3–4=8.6, 95% CI=4.3–17.0; OR for a score of ≥5=15.0, 95% CI=6.5–34.5).
CONCLUSION: The medication regimens of older adults present a range of difficulties with the potential for harm. Strategies are needed that specifically address the management of complex drug regimens.