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Serum Calcium and Cognitive Function in Old Age

Authors

  • Miranda T. Schram PhD,

    1. From the *Department of Gerontology and Geriatrics, Leiden University Medical Centre, Leiden, The NetherlandsDepartment of Epidemiology and Biostatistics, Erasmus MC, Rotterdam, The Netherlands.
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  • , Stella Trompet MSc,

    1. From the *Department of Gerontology and Geriatrics, Leiden University Medical Centre, Leiden, The NetherlandsDepartment of Epidemiology and Biostatistics, Erasmus MC, Rotterdam, The Netherlands.
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  • Adriaan M. Kamper MD, PhD,

    1. From the *Department of Gerontology and Geriatrics, Leiden University Medical Centre, Leiden, The NetherlandsDepartment of Epidemiology and Biostatistics, Erasmus MC, Rotterdam, The Netherlands.
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  • Anton J. M. De Craen PhD,

    1. From the *Department of Gerontology and Geriatrics, Leiden University Medical Centre, Leiden, The NetherlandsDepartment of Epidemiology and Biostatistics, Erasmus MC, Rotterdam, The Netherlands.
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  • Albert Hofman MD, PhD,

    1. From the *Department of Gerontology and Geriatrics, Leiden University Medical Centre, Leiden, The NetherlandsDepartment of Epidemiology and Biostatistics, Erasmus MC, Rotterdam, The Netherlands.
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  • Sjoerd M. Euser MSc,

    1. From the *Department of Gerontology and Geriatrics, Leiden University Medical Centre, Leiden, The NetherlandsDepartment of Epidemiology and Biostatistics, Erasmus MC, Rotterdam, The Netherlands.
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  • , Monique M. B. Breteler MD, PhD,

    1. From the *Department of Gerontology and Geriatrics, Leiden University Medical Centre, Leiden, The NetherlandsDepartment of Epidemiology and Biostatistics, Erasmus MC, Rotterdam, The Netherlands.
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  • Rudi G. J. Westendorp MD, PhD

    1. From the *Department of Gerontology and Geriatrics, Leiden University Medical Centre, Leiden, The NetherlandsDepartment of Epidemiology and Biostatistics, Erasmus MC, Rotterdam, The Netherlands.
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Address correspondence to Miranda T. Schram, Department of Gerontology and Geriatrics C-02-R, Leiden University Medical Centre, PO Box 9600, 2300 RC Leiden, The Netherlands. E-mail: m.vanmeeteren@lumc.nl

Abstract

OBJECTIVES: To determine whether serum calcium is associated with cognitive function in elderly individuals in the general population.

DESIGN: Prospective follow-up study of two independent, population-based cohorts.

SETTING: The Rotterdam Study (median follow-up 11 years) and the Leiden 85-plus Study (median follow-up 5 years).

PARTICIPANTS: Three thousand nine hundred ninety-four individuals, mean age 71, from the Rotterdam Study and 560 individuals, all aged 85, from the Leiden 85-plus Study.

MEASUREMENTS: Global cognitive function was assessed in both cohorts using the Mini-Mental State Examination; attention, psychomotor speed, and memory function were assessed in the Leiden 85-plus Study only. Linear regression and linear mixed models were used for statistical analyses.

RESULTS: In the Rotterdam Study, high serum calcium was associated with worse global cognitive function at baseline (P<.05) and a faster rate of decline in cognitive function during follow-up (P=.005) in individuals aged 75 and older but not in younger individuals. In the Leiden 85-plus Study, high serum calcium was associated with worse global cognitive function from age 85 through 90 (P<.001). This observation also held for the specific cognitive domains tested (all P<.01). These results did not change when individuals with serum calcium levels greater than normal (>2.55 mmol/L) were excluded from the analyses.

CONCLUSION: In the general population, high serum calcium levels are associated with faster decline in cognitive function over the age of 75.

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