Muscle Endurance in Elderly Nursing Home Residents Is Related to Fatigue Perception, Mobility, and Circulating Tumor Necrosis Factor-Alpha, Interleukin-6, and Heat Shock Protein 70
(See editorial comments by Drs. Hermes Florez and Bruce R. Troen, pp 558–560)
Article first published online: 27 DEC 2007
© 2007, Copyright the Authors; Journal compilation © 2008, The American Geriatrics Society
Journal of the American Geriatrics Society
Volume 56, Issue 3, pages 389–396, March 2008
How to Cite
Bautmans, I., Njemini, R., Predom, H., Lemper, J.-C. and Mets, T. (2008), Muscle Endurance in Elderly Nursing Home Residents Is Related to Fatigue Perception, Mobility, and Circulating Tumor Necrosis Factor-Alpha, Interleukin-6, and Heat Shock Protein 70. Journal of the American Geriatrics Society, 56: 389–396. doi: 10.1111/j.1532-5415.2007.01571.x
- Issue published online: 27 DEC 2007
- Article first published online: 27 DEC 2007
- heat shock protein;
- muscle endurance;
- nursing homes;
OBJECTIVES: To explore the relationships between muscle endurance and circulating interleukin (IL)-6, tumor necrosis factor alpha (TNF-α), and heat shock protein (Hsp)70 in nursing home residents and to assess how muscle endurance relates to self-perceived fatigue and mobility.
DESIGN: Exploratory study.
SETTING: Three nursing homes of the Foundation for Psychogeriatrics (Brussels, Belgium).
PARTICIPANTS: Seventy-seven residents (53 female and 24 male, mean age 81 ± 8).
MEASUREMENTS: Participants were assessed for muscle endurance (fatigue resistance and grip work); perceived fatigue (visual analogue scale for fatigue); fatigue during daily activities (Mobility-Tiredness Scale); effect of fatigue on quality of life (World Health Organization Quality Of Life questionnaire); mobility (Tinetti Test & Elderly Mobility Scale (EMS)); and circulating IL-6, TNF-α, and Hsp70.
RESULTS: Residents with better fatigue resistance reported less self-perceived tiredness (P<.05). Similar trends were observed for fatigue during daily activities and for the extent to which fatigue bothered subjects. Higher grip work was associated with less self-perceived fatigue on all fatigue scales (P<.01). Fatigue resistance and grip work were positively related to balance and basic mobility (all P<.01; trend for relationship between fatigue resistance and EMS). Subjects with high IL-6 and Hsp70 showed significantly worse fatigue resistance (P=.007) and muscle work (P=.045) than those with high IL-6 and low Hsp70. In male residents, higher TNF-α was related to worse fatigue resistance and grip work (P<.05).
CONCLUSION: Elderly nursing home residents complaining of fatigue need to be taken seriously, because they show worse muscle endurance, which is related to poorer mobility. Inflammatory processes involving TNF-α and the interaction between IL-6 and Hsp70 are related to poorer muscle endurance in these patients.