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Apolipoprotein E ɛ4, Alzheimer's Disease, and Cognitive Performance in Elderly Mexican Mestizos
Article first published online: 18 JAN 2008
DOI: 10.1111/j.1532-5415.2007.01606.x
© 2008, Copyright the Authors
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How to Cite
Villalpando-Berumen, J. M., Mejia-Arango, S., Aguilar-Salinas, C. A., Ordonez-Sanchez, M. L. and Gutierrez-Robledo, L. M. (2008), Apolipoprotein E ɛ4, Alzheimer's Disease, and Cognitive Performance in Elderly Mexican Mestizos. Journal of the American Geriatrics Society, 56: 677–682. doi: 10.1111/j.1532-5415.2007.01606.x
Publication History
- Issue published online: 18 JAN 2008
- Article first published online: 18 JAN 2008
- Abstract
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Keywords:
- APOE;
- Alzheimer's disease;
- cognition;
- Mexican;
- Mestizo
OBJECTIVES: To determine the relationship between apolipoprotein E (APOE) ɛ4 and Alzheimer's disease (AD) in the Mexican Mestizo population, as well as its effects on the cognitive profile of AD and elderly Mestizos without dementia.
DESIGN: Cross-sectional analysis of a cohort study.
SETTING: Evaluations were conducted at the geriatrics clinic of an academic medical hospital in Mexico City.
PARTICIPANTS: Forty-nine elderly subjects with AD and 141 controls selected from a representative sample of Mexican Mestizos aged 65 to 96 who participated in the Prevalence Survey of Dementia in the Mexico City Elderly Population cohort.
MEASUREMENTS: All subjects underwent APOE genotypification and a comprehensive clinical and neuropsychological evaluation.
RESULTS: There were no significant differences in ɛ3 and ɛ4 frequencies between the subjects with and without AD and a tendency toward higher ɛ4 and lower ɛ3 allele frequencies in subjects aged 75 and older. No association was found between APOE ɛ4 and the presence of AD. The age-, sex-, and education-adjusted risk for AD associated with at least one ɛ4 allele was 1.01 (95% confidence interval=0.45–2.23). Performance on a long-term visual memory test was significantly worse in APOE ɛ4 carriers than in APOE ɛ3 carriers only in the group with AD.
CONCLUSION: APOE ɛ4 did not increase the risk for AD in this Mexican Mestizo elderly urban population sample, although the presence of this allele seems to modify its clinical expression.