Hematopoietic Capacity and Exceptional Survival: The Leiden Longevity Study

Authors

  • Jorien M. Willems MD,

    1. From the Departments of *Gerontology and GeriatricsMolecular Epidemiology, Leiden University Medical Center, Leiden, the Netherlands
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  • Stella Trompet MSc,

    1. From the Departments of *Gerontology and GeriatricsMolecular Epidemiology, Leiden University Medical Center, Leiden, the Netherlands
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  • P. Eline Slagboom PhD,

    1. From the Departments of *Gerontology and GeriatricsMolecular Epidemiology, Leiden University Medical Center, Leiden, the Netherlands
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  • Anton J.M. De Craen PhD,

    1. From the Departments of *Gerontology and GeriatricsMolecular Epidemiology, Leiden University Medical Center, Leiden, the Netherlands
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  • Rudi G.J. Westendorp MD, PhD

    1. From the Departments of *Gerontology and GeriatricsMolecular Epidemiology, Leiden University Medical Center, Leiden, the Netherlands
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Address correspondence to Jorien M Willems, MD, Department of Gerontology and Geriatrics, C-2-R, Leiden University Medical Center, PO Box 9600, 2300 RC, Leiden, the Netherlands. E-mail: j.m.willems@lumc.nl

Abstract

OBJECTIVES: To assess whether familial longevity can be attributed to sustained hematopoietic capacity.

DESIGN: Prospective follow-up study of two independent population-based cohorts.

SETTING: The Leiden Longevity Study and the Leiden 85-plus Study.

PARTICIPANTS: From the Leiden Longevity Study, 1,001 nonagenarians with familial longevity were included. As age-matched controls, 260 nonagenarians without familial longevity were used from the Leiden 85-plus Study.

MEASUREMENTS: Hemoglobin, leukocytes, and thrombocytes were measured for all subjects with and without familial longevity. Standardized mortality ratios, linear regression, and left-censored Cox regression were used for statistical analysis.

RESULTS: Mortality in nonagenarians with familial longevity was 28% lower than in nonagenarians from the general population (standardized mortality ratio=0.72, 95% confidence interval (CI)=0.65–0.79, P<.001). No differences were found between hemoglobin, leukocyte, and thrombocyte count in nonagenarians with and without familial longevity (all P>.30). Nonagenarians with familial longevity had greater mortality risk when anemia was present (sex-adjusted hazard ratio=1.71, 95% CI 1.41–2.07, P<.001). No relationship was found between leukocytes, thrombocytes, and mortality in either study group (all P>.20).

CONCLUSION: Hematopoietic capacity cannot explain the significantly better survival of nonagenarians with familial longevity, but in those with familial longevity, anemia may contribute to mortality.

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