Presented in part at The Gerontological Society of America Annual Meeting, San Francisco, California, November 19, 2007.
Exercise Training and Plasma C-Reactive Protein and Interleukin-6 in Elderly People
Article first published online: 15 OCT 2008
© 2008, Copyright the Authors. Journal compilation © 2008, The American Geriatrics Society
Journal of the American Geriatrics Society
Volume 56, Issue 11, pages 2045–2052, November 2008
How to Cite
Nicklas, B. J., Hsu, F.-C., Brinkley, T. J., Church, T., Goodpaster, B. H., Kritchevsky, S. B. and Pahor, M. (2008), Exercise Training and Plasma C-Reactive Protein and Interleukin-6 in Elderly People. Journal of the American Geriatrics Society, 56: 2045–2052. doi: 10.1111/j.1532-5415.2008.01994.x
- Issue published online: 3 NOV 2008
- Article first published online: 15 OCT 2008
- exercise training;
- C-reactive protein
OBJECTIVES: To determine the effects of a long-term exercise intervention on two prominent biomarkers of inflammation (C-reactive protein (CRP) and interleukin-6 (IL-6)) in elderly men and women.
DESIGN: Single-blind, randomized, controlled trial: The Lifestyle Interventions and Independence for Elders (LIFE) Trial.
SETTING: The Cooper Institute, Dallas, Texas; Stanford University, Stanford, California; University of Pittsburgh, Pittsburgh, Pennsylvania; and Wake Forest University, Winston-Salem, North Carolina.
PARTICIPANTS: Four hundred twenty-four elderly (aged 70–89), nondisabled, community-dwelling men and women at risk for physical disability.
INTERVENTION: A 12-month moderate-intensity physical activity (PA) intervention and a successful aging (SA) health education intervention.
MEASUREMENTS: CRP and IL-6.
RESULTS: After adjustment for baseline IL-6, sex, clinic site, diabetes mellitus, treatment group, visit, and group-by-visit interaction, the PA intervention resulted in a lower (P=.02) IL-6 concentration than the SA intervention. Adjusted mean IL-6 at month 12 was 8.5% (0.21 pg/mL) higher in the SA than the PA group. There were no significant differences in CRP between the groups at 12 months (P=.09). Marginally significant interaction effects of the PA intervention according to baseline functional status (P=.05) and IL-6 (above vs below the median; P=.06) were observed. There was a greater effect of the PA intervention on participants with lower functional status and those with a higher baseline IL-6.
CONCLUSION: Greater PA results in lower systemic concentrations of IL-6 in elderly individuals, and this benefit is most pronounced in individuals at the greatest risk for disability and subsequent loss of independence.