Serum Insulin-Like Growth Factor-1 Binding Proteins 1 and 2 and Mortality in Older Adults: The Health, Aging, and Body Composition Study
Article first published online: 3 JUN 2009
© 2009, Copyright the Authors. Journal compilation © 2009, The American Geriatrics Society
Journal of the American Geriatrics Society
Volume 57, Issue 7, pages 1213–1218, July 2009
How to Cite
Hu, D., Pawlikowska, L., Kanaya, A., Hsueh, W.-C., Colbert, L., Newman, A. B., Satterfield, S., Rosen, C., Cummings, S. R., Harris, T. B., Ziv, E. and for the Health, Aging, and Body Composition Study (2009), Serum Insulin-Like Growth Factor-1 Binding Proteins 1 and 2 and Mortality in Older Adults: The Health, Aging, and Body Composition Study. Journal of the American Geriatrics Society, 57: 1213–1218. doi: 10.1111/j.1532-5415.2009.02318.x
- Issue published online: 30 JUN 2009
- Article first published online: 3 JUN 2009
OBJECTIVE: To evaluate the relationship between serum insulin-like growth factor 1 (IGF-1), IGF-1 binding protein 1 (IGFBP-1), and IGF-1 binding protein 2 (IGFBP-2) and fasting insulin, fasting glucose, adiposity, and mortality in older adults.
DESIGN: A prospective cohort study with mean follow-up of 6.2 years.
SETTING: Participants were recruited and followed at two centers affiliated with academic medical institutions.
PARTICIPANTS: Six hundred twenty-five men and women aged 70 and older and in good health at the time of enrollment.
MEASUREMENTS: Serum IGF-1, IGFBP-1, and IGFBP-2; fasting serum insulin; fasting serum glucose; visceral fat; and total percent fat.
RESULTS: Higher IGFBP-1 and higher IGFBP-2 were significantly associated with lower fasting insulin, lower fasting glucose, and lower adiposity, but higher IGFBP-1 and IGFBP-2 were associated with greater mortality. In multivariate adjusted models, the hazard ratio for all-cause mortality was 1.48 (95% confidence interval (CI)=1.14–1.92) per standard deviation (SD) increase in IGFBP-2 and 1.34 (95% CI=1.01–1.76) per SD increase in IGFBP-1. No association was found between IGF-1 and all-cause mortality.
CONCLUSIONS: Higher IGFBP-1 and IGFBP-2 are associated with lower adiposity and decreased glucose tolearance but also with greater all-cause mortality. Higher levels of serum IGF-1 binding protein (IGFBP) may indicate greater IGF-1 activity and thus represent an association between higher IGF-1 activity and mortality in humans.