A Randomized, Single-Blind Study of Lansoprazole for the Prevention of Exacerbations of Chronic Obstructive Pulmonary Disease in Older Patients

  1. Takahiko Sasaki MD, PhD,
  2. Katsutoshi Nakayama MD, PhD,
  3. Hiroyasu Yasuda MD, PhD,
  4. Motoki Yoshida MD,
  5. Takaaki Asamura MD,
  6. Takashi Ohrui MD, PhD,
  7. Hiroyuki Arai MD, PhD,
  8. Jun Araya MD, PhD,
  9. Kazuyoshi Kuwano MD, PhD,
  10. Mutsuo Yamaya MD, PhD

Article first published online: 8 JUN 2009

DOI: 10.1111/j.1532-5415.2009.02349.x

Issue

Journal of the American Geriatrics Society

Journal of the American Geriatrics Society

Volume 57, Issue 8, pages 1453–1457, August 2009

Additional Information

How to Cite

Sasaki, T., Nakayama, K., Yasuda, H., Yoshida, M., Asamura, T., Ohrui, T., Arai, H., Araya, J., Kuwano, K. and Yamaya, M. (2009), A Randomized, Single-Blind Study of Lansoprazole for the Prevention of Exacerbations of Chronic Obstructive Pulmonary Disease in Older Patients. Journal of the American Geriatrics Society, 57: 1453–1457. doi: 10.1111/j.1532-5415.2009.02349.x

Author Information

  1. From the Departments of *Geriatric and Gerontology and §Advanced Preventive Medicine for Infectious Disease, School of Medicine, Tohoku University, Sendai, Japan†Department of Translational Clinical Oncology, Graduate School of Medicine, Kyoto University, Kyoto, Japan; and ‡Division of Respiratory Diseases, Department of Internal Medicine, School of Medicine, Jikei University, Tokyo, Japan.

*Address correspondence to Katsutoshi Nakayama, Division of Respiratory Diseases, Department of Internal Medicine, Jikei University School of Medicine, 3-25-8 Nishi-shinbashi, Minato-ku, Tokyo 105-8461, Japan. E-mail: kat_n1@jikei.ac.jp

Publication History

  1. Issue published online: 29 JUL 2009
  2. Article first published online: 8 JUN 2009

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Keywords:

  • proton pump inhibitor;
  • chronic obstructive pulmonary disease;
  • exacerbation;
  • common cold;
  • lower airway infection

OBJECTIVES: To investigate whether proton pump inhibitor (PPI) therapy reduces the frequency of common colds and exacerbations in patients with chronic obstructive pulmonary disease (COPD).

DESIGN: Twelve-month, randomized, observer-blind, controlled trial.

SETTING: A university hospital and three city hospitals in Miyagi prefecture in Japan.

PARTICIPANTS: One hundred patients with COPD (mean age ± SD 74.9 ± 8.2) participated. They were all ex-smokers and had received conventional therapies for COPD, including smoking cessation and bronchodilators. Patients with gastroesophageal reflux disease or gastroduodenal ulcer were excluded.

INTERVENTION: Patients were randomly assigned to conventional therapies (control group) or conventional therapies plus PPI (lansoprazole 15 mg/d; PPI group) and observed for 12 months.

MEASUREMENTS: Frequency of common colds and COPD exacerbations.

RESULTS: The number of exacerbations per person in a year in the PPI group was significantly lower than that in the control group (0.34 ± 0.72 vs 1.18 ± 1.40; P<.001). The adjusted odds ratio with logistic regression for having exacerbation (≥once/year) in the PPI group compared with the control group was 0.23 (P=.004). In contrast, there was no significant difference in the numbers of common colds per person per year between the PPI group and the control group (1.22 ± 2.09 vs 2.04 ± 3.07; P=.12). PPI therapy significantly reduced the risk of catching frequent common colds (≥3 times/year), the adjusted odds ratio of which was 0.28 (P=.048).

CONCLUSION: In this single-blind, nonplacebo-controlled trial, lansoprazole was associated with a significant decrease in COPD exacerbations. More definitive clinical trials are warranted.

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