Magnetic Resonance Imaging Volume of the Angular Gyri Predicts Financial Skill Deficits in People with Amnestic Mild Cognitive Impairment

Authors

  • H. Randall Griffith PhD,

    1. From the Departments of *Neurology, Psychology, and #Cardiology, and Alzheimer's Disease Research Center, University of Alabama at Birmingham, Birmingham, Alabama; §Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts; Department of Neurology, School of Medicine, the Johns Hopkins University, Baltimore, Maryland; and **Birmingham Regional Veterans Affairs Medical Center, Birmingham, Alabama
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  • Christopher C. Stewart MS,

    1. From the Departments of *Neurology, Psychology, and #Cardiology, and Alzheimer's Disease Research Center, University of Alabama at Birmingham, Birmingham, Alabama; §Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts; Department of Neurology, School of Medicine, the Johns Hopkins University, Baltimore, Maryland; and **Birmingham Regional Veterans Affairs Medical Center, Birmingham, Alabama
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  • Luke E. Stoeckel PhD,

    1. From the Departments of *Neurology, Psychology, and #Cardiology, and Alzheimer's Disease Research Center, University of Alabama at Birmingham, Birmingham, Alabama; §Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts; Department of Neurology, School of Medicine, the Johns Hopkins University, Baltimore, Maryland; and **Birmingham Regional Veterans Affairs Medical Center, Birmingham, Alabama
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  • Ozioma C. Okonkwo PhD,

    1. From the Departments of *Neurology, Psychology, and #Cardiology, and Alzheimer's Disease Research Center, University of Alabama at Birmingham, Birmingham, Alabama; §Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts; Department of Neurology, School of Medicine, the Johns Hopkins University, Baltimore, Maryland; and **Birmingham Regional Veterans Affairs Medical Center, Birmingham, Alabama
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  • Jan A. den Hollander PhD,

    1. From the Departments of *Neurology, Psychology, and #Cardiology, and Alzheimer's Disease Research Center, University of Alabama at Birmingham, Birmingham, Alabama; §Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts; Department of Neurology, School of Medicine, the Johns Hopkins University, Baltimore, Maryland; and **Birmingham Regional Veterans Affairs Medical Center, Birmingham, Alabama
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  • Roy C. Martin PhD,

    1. From the Departments of *Neurology, Psychology, and #Cardiology, and Alzheimer's Disease Research Center, University of Alabama at Birmingham, Birmingham, Alabama; §Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts; Department of Neurology, School of Medicine, the Johns Hopkins University, Baltimore, Maryland; and **Birmingham Regional Veterans Affairs Medical Center, Birmingham, Alabama
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  • Katherine Belue BS,

    1. From the Departments of *Neurology, Psychology, and #Cardiology, and Alzheimer's Disease Research Center, University of Alabama at Birmingham, Birmingham, Alabama; §Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts; Department of Neurology, School of Medicine, the Johns Hopkins University, Baltimore, Maryland; and **Birmingham Regional Veterans Affairs Medical Center, Birmingham, Alabama
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  • Jacquelynn N. Copeland BS,

    1. From the Departments of *Neurology, Psychology, and #Cardiology, and Alzheimer's Disease Research Center, University of Alabama at Birmingham, Birmingham, Alabama; §Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts; Department of Neurology, School of Medicine, the Johns Hopkins University, Baltimore, Maryland; and **Birmingham Regional Veterans Affairs Medical Center, Birmingham, Alabama
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  • Lindy E. Harrell MD, PhD,

    1. From the Departments of *Neurology, Psychology, and #Cardiology, and Alzheimer's Disease Research Center, University of Alabama at Birmingham, Birmingham, Alabama; §Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts; Department of Neurology, School of Medicine, the Johns Hopkins University, Baltimore, Maryland; and **Birmingham Regional Veterans Affairs Medical Center, Birmingham, Alabama
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  • John C. Brockington MD,

    1. From the Departments of *Neurology, Psychology, and #Cardiology, and Alzheimer's Disease Research Center, University of Alabama at Birmingham, Birmingham, Alabama; §Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts; Department of Neurology, School of Medicine, the Johns Hopkins University, Baltimore, Maryland; and **Birmingham Regional Veterans Affairs Medical Center, Birmingham, Alabama
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  • David G. Clark MD,

    1. From the Departments of *Neurology, Psychology, and #Cardiology, and Alzheimer's Disease Research Center, University of Alabama at Birmingham, Birmingham, Alabama; §Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts; Department of Neurology, School of Medicine, the Johns Hopkins University, Baltimore, Maryland; and **Birmingham Regional Veterans Affairs Medical Center, Birmingham, Alabama
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  • Daniel C. Marson JD, PhD

    1. From the Departments of *Neurology, Psychology, and #Cardiology, and Alzheimer's Disease Research Center, University of Alabama at Birmingham, Birmingham, Alabama; §Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts; Department of Neurology, School of Medicine, the Johns Hopkins University, Baltimore, Maryland; and **Birmingham Regional Veterans Affairs Medical Center, Birmingham, Alabama
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Address correspondence to H. Randall Griffith, ABPP-CN; SC 650, 1530 3rd Ave. S., Birmingham, AL 35294. E-mail: rlgriffith@uabmc.edu

Abstract

OBJECTIVES: To better understand how brain atrophy in amnestic mild cognitive impairment (MCI) as measured using magnetic resonance imaging (MRI) volumetrics could affect instrumental activities of daily living (IADLs) such as financial abilities.

DESIGN: Controlled, matched-sample, cross-sectional analysis regressing MRI volumetrics with financial performance measures.

SETTING: University medical and research center.

PARTICIPANTS: Thirty-eight people with MCI and 28 older adult controls.

MEASUREMENTS: MRI volumetric measurement of the hippocampi, angular gyri, precunei, and medial frontal lobes. Participants also completed neuropsychological tests and the Financial Capacity Instrument (FCI).

RESULTS: Correlations were performed between FCI scores and MRI volumes in the group with MCI. People with MCI performed significantly below controls on the FCI and had significantly smaller hippocampi. Among people with MCI, performance on the FCI was moderately correlated with angular gyri and precunei volumes. Regression models demonstrated that angular gyrus volumes were predictive of FCI scores. Tests of mediation showed that measures of arithmetic and possibly attention partially mediated the relationship between angular gyrus volume and FCI score.

CONCLUSION: Impaired financial abilities in amnestic MCI correspond with volume of the angular gyri as mediated by arithmetic knowledge. The findings suggest that early neuropathology within the lateral parietal region in MCI leads to a breakdown of cognitive abilities that affect everyday financial skills. The findings have implications for diagnosis and clinical care of people with MCI and AD.

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