• 1
    Vermeer SE, Den Heijer T, Koudstaal PJ et al. Incidence and risk factors of silent brain infarcts in the population-based Rotterdam Scan Study. Stroke 2003;34:392396.
  • 2
    Benson R, Guttmann C, Wei X et al. Older people with impaired mobility have specific loci of perventricular abnormality on MRI. Neurology 2002;58:4855.
  • 3
    Baloh RW, Yue Q, Socotch TM et al. White matter lesions and disequilibrium in older people. I. Case-control comparison. Arch Neurol 1995;52:970974.
  • 4
    Sakakibara R, Hattori T, Uchiyama T et al. Urinary function in elderly people with and without leukoaraiosis: Relation to cognitive and gait function. J Neurol Neurosurg Psychiatry 1999;67:658660.
  • 5
    Junque C, Pujol J, Vendrell P et al. Leuko-araiosis on magnetic resonance imaging and speed of mental processing. Arch Neurol 1990;47:151156.
  • 6
    Kaplan RF, Cohen RA, Moscufo N et al. Demographic and biological influences on cognitive reserve. J Clin Exp Neuropsychol Mar 2009;31:19.
  • 7
    Moscufo N, Guttmann CRG, Meier D et al. Brain regional lesion burden and impaired mobility in the elderly. Neurobiol Aging 2009 May 8. [Epub ahead of print].
  • 8
    Kuchel GA, Moscufo N, Guttmann CR et al. Localization of brain white matter hyperintensities and urinary incontinence in community-dwelling older adults. J Gerontol A Biol Sci Med Sci 2009;64A:902909.
  • 9
    Hanley J, Capewell A, Hagen S. Validity study of the severity index, a simple measure of urinary incontinence in women. BMJ 2001;322:10961097.
  • 10
    Guralnik JM, Simonsick EM, Ferrucci L et al. A short physical performance battery assessing lower extremity function: Association with self-reported disability and prediction of mortality and nursing home admission. J Gerontol 1994;49:M85M94.
  • 11
    Tinetti ME. Performance-oriented assessment of mobility problems in elderly patients. J Am Geriatr Soc 1986;34:119126.
  • 12
    Lezak MD. Neuropsychological Assessment, 3rd Ed. New York: Oxford University Press, 1995.
  • 13
    Golden CJ, Freshwater SM. The Stroop Color and Word Test: A Manual for Clinical and Experimental Uses. Wood Dale, IL: Stoelting, 2002.
  • 14
    Sled JG, Zijdenbos AP, Evans AC. A nonparametric method for automatic correction of intensity nonuniformity in MRI data. IEEE Trans Med Imaging 1998;17:8797.
  • 15
    Jenkinson M, Smith S. A global optimisation method for robust affine registration of brain images. Med Image Anal 2001;5:143156.
  • 16
    Fischl B, Salat DH, Busa E et al. Whole brain segmentation: Automated labeling of neuroanatomical structures in the human brain. Neuron 2002;33:341355.
  • 17
    Pohl KM, Bouix S, Kikinis R et al Anatomical guided segmentation with non-stationary tissue class distributions in an expectation-maximization framework. IEEE International Symposium on Biomedical Imaging: From Nano to Macro, Arlington, VA. 2004; 81–84.
  • 18
    Mori S, Oishi K, Jiang H et al. Stereotaxic white matter atlas based on diffusion tensor imaging in an ICBM template. Neuroimage 2008;40:570582.
  • 19
    Tinetti ME, Inouye SK, Gill TM et al. Shared risk factors for falls, incontinence, and functional dependence. Unifying the approach to geriatric syndromes. JAMA 1995;273:13481353.
  • 20
    Inouye SK, Ferrucci L. Elucidating the pathophysiology of delirium and the interrelationship of delirium and dementia. J Gerontol A Biol Sci Med Sci 2006;61A:12771280.
  • 21
    Toga AW, Thompson PM, Mori S et al. Towards multimodal atlases of the human brain. Nat Rev Neurosci 2006;7:952966.
  • 22
    Inouye SK, Studenski S, Tinetti ME et al. Geriatric syndromes: Clinical, research, and policy implications of a core geriatric concept. J Am Geriatr Soc 2007;55:780791.
  • 23
    Prins ND, van Straaten EC, van Dijk EJ et al. Measuring progression of cerebral white matter lesions on MRI: Visual rating and volumetrics. Neurology 2004;62:15331539.
  • 24
    Holland CM, Smith EE, Csapo I et al. Spatial distribution of white-matter hyperintensities in Alzheimer disease, cerebral amyloid angiopathy, and healthy aging. Stroke 2008;39:11271133.
  • 25
    Wolfson L, Wei X, Hall CB et al. Accrual of MRI white matter abnormalities in elderly with normal and impaired mobility. J Neurol Sci 2005;232:2327.