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Favorable Glucose Tolerance and Lower Prevalence of Metabolic Syndrome in Offspring without Diabetes Mellitus of Nonagenarian Siblings: The Leiden Longevity Study

Authors

  • Maarten P. Rozing MD,

    1. From the Departments of *Gerontology and Geriatrics, Clinical Chemistry, and §Molecular Epidemiology, Leiden University Medical Center, Leiden, the Netherlands; and Netherlands Consortium of Healthy Aging, the Netherlands.
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  • Rudi G. J. Westendorp MD, PhD,

    1. From the Departments of *Gerontology and Geriatrics, Clinical Chemistry, and §Molecular Epidemiology, Leiden University Medical Center, Leiden, the Netherlands; and Netherlands Consortium of Healthy Aging, the Netherlands.
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  • Anton J. M. de Craen PhD,

    1. From the Departments of *Gerontology and Geriatrics, Clinical Chemistry, and §Molecular Epidemiology, Leiden University Medical Center, Leiden, the Netherlands; and Netherlands Consortium of Healthy Aging, the Netherlands.
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  • Marijke Frölich PhD,

    1. From the Departments of *Gerontology and Geriatrics, Clinical Chemistry, and §Molecular Epidemiology, Leiden University Medical Center, Leiden, the Netherlands; and Netherlands Consortium of Healthy Aging, the Netherlands.
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  • Moniek C. M. de Goeij BSc,

    1. From the Departments of *Gerontology and Geriatrics, Clinical Chemistry, and §Molecular Epidemiology, Leiden University Medical Center, Leiden, the Netherlands; and Netherlands Consortium of Healthy Aging, the Netherlands.
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  • Bastiaan T. Heijmans PhD,

    1. From the Departments of *Gerontology and Geriatrics, Clinical Chemistry, and §Molecular Epidemiology, Leiden University Medical Center, Leiden, the Netherlands; and Netherlands Consortium of Healthy Aging, the Netherlands.
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  • Marian Beekman PhD,

    1. From the Departments of *Gerontology and Geriatrics, Clinical Chemistry, and §Molecular Epidemiology, Leiden University Medical Center, Leiden, the Netherlands; and Netherlands Consortium of Healthy Aging, the Netherlands.
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  • Carolien A. Wijsman PhD,

    1. From the Departments of *Gerontology and Geriatrics, Clinical Chemistry, and §Molecular Epidemiology, Leiden University Medical Center, Leiden, the Netherlands; and Netherlands Consortium of Healthy Aging, the Netherlands.
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  • Simon P. Mooijaart MD, PhD,

    1. From the Departments of *Gerontology and Geriatrics, Clinical Chemistry, and §Molecular Epidemiology, Leiden University Medical Center, Leiden, the Netherlands; and Netherlands Consortium of Healthy Aging, the Netherlands.
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  • Gerard-Jan Blauw MD, PhD,

    1. From the Departments of *Gerontology and Geriatrics, Clinical Chemistry, and §Molecular Epidemiology, Leiden University Medical Center, Leiden, the Netherlands; and Netherlands Consortium of Healthy Aging, the Netherlands.
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  • P. Eline Slagboom PhD,

    1. From the Departments of *Gerontology and Geriatrics, Clinical Chemistry, and §Molecular Epidemiology, Leiden University Medical Center, Leiden, the Netherlands; and Netherlands Consortium of Healthy Aging, the Netherlands.
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  • Diana van Heemst PhD,

    1. From the Departments of *Gerontology and Geriatrics, Clinical Chemistry, and §Molecular Epidemiology, Leiden University Medical Center, Leiden, the Netherlands; and Netherlands Consortium of Healthy Aging, the Netherlands.
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  • on behalf of the Leiden Longevity Study Group

    1. From the Departments of *Gerontology and Geriatrics, Clinical Chemistry, and §Molecular Epidemiology, Leiden University Medical Center, Leiden, the Netherlands; and Netherlands Consortium of Healthy Aging, the Netherlands.
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Address correspondence to Diana van Heemst, Department of Gerontology and Geriatrics, Leiden University Medical Center, PO Box 9600, 2300 RC, Leiden, the Netherlands, E-mail: D.van_Heemst@lumc.nl

Abstract

OBJECTIVES: To explore measures of metabolic syndrome and glucose metabolism in families with exceptional longevity.

DESIGN: Case–control study.

SETTING: A university hospital in Leiden, the Netherlands.

PARTICIPANTS: One hundred twenty-one offspring of nonagenarian siblings, who were enriched for familial factors promoting longevity, and 113 of their partners. No subject had diabetes mellitus.

MEASUREMENTS: Prevalence of metabolic syndrome was determined according to the criteria of the Third Report of the National Cholesterol Education Program. Glucose tolerance was assessed according to a 2-hour oral glucose tolerance test.

RESULTS: The offspring of nonagenarians siblings had a lower prevalence of metabolic syndrome (P=.03), similar body composition, lower mean fasting blood glucose levels (4.99 vs 5.16 mmol/L; P=.01), lower mean fasting insulin levels (5.81 vs 6.75 mU/L; P=.04), a higher mean homeostasis model assessment of insulin sensitivity (0.78 vs 0.65; P=.02), and a more-favorable glucose tolerance (mean area under the receiver operating characteristic curve for glucose (13.2 vs 14.3; P=.007) than their partners. No significant differences were observed between the offspring and their partners in β-cell function (insulogenic index 13.6 vs 12.5; P=.38).

CONCLUSION: Despite similar body composition, the offspring of nonagenarian siblings showed a lower prevalence of metabolic syndrome and better glucose tolerance than their partners, centralizing the role of favorable glucose metabolism in familial longevity.

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