Daily Medication Use in Nursing Home Residents with Advanced Dementia

Authors

  • Jennifer Tjia MD, MSCE,

    1. From the *Division of Geriatric Medicine, University of Massachusetts Medical School, Worcester, Massachusetts; University of New England College of Osteopathic Medicine, Biddeford, Maine; Hebrew SeniorLife Institute for Aging Research, Boston, Massachusetts; §Department of Public Health Sciences, PennState College of Medicine, Hershey, Pennsylvania; Division of General Internal Medicine, MD Anderson Cancer Center, University of Texas, Houston, Texas; #Division of General Internal Medicine and Geriatrics, and **Center for Aging Research, Regenstrief Institute Inc., Indiana University, Indianapolis, Indiana.
    Search for more papers by this author
  • Margaret R. Rothman MA,

    1. From the *Division of Geriatric Medicine, University of Massachusetts Medical School, Worcester, Massachusetts; University of New England College of Osteopathic Medicine, Biddeford, Maine; Hebrew SeniorLife Institute for Aging Research, Boston, Massachusetts; §Department of Public Health Sciences, PennState College of Medicine, Hershey, Pennsylvania; Division of General Internal Medicine, MD Anderson Cancer Center, University of Texas, Houston, Texas; #Division of General Internal Medicine and Geriatrics, and **Center for Aging Research, Regenstrief Institute Inc., Indiana University, Indianapolis, Indiana.
    Search for more papers by this author
  • Dan K. Kiely MPH, MA,

    1. From the *Division of Geriatric Medicine, University of Massachusetts Medical School, Worcester, Massachusetts; University of New England College of Osteopathic Medicine, Biddeford, Maine; Hebrew SeniorLife Institute for Aging Research, Boston, Massachusetts; §Department of Public Health Sciences, PennState College of Medicine, Hershey, Pennsylvania; Division of General Internal Medicine, MD Anderson Cancer Center, University of Texas, Houston, Texas; #Division of General Internal Medicine and Geriatrics, and **Center for Aging Research, Regenstrief Institute Inc., Indiana University, Indianapolis, Indiana.
    Search for more papers by this author
  • Michele L. Shaffer PhD,

    1. From the *Division of Geriatric Medicine, University of Massachusetts Medical School, Worcester, Massachusetts; University of New England College of Osteopathic Medicine, Biddeford, Maine; Hebrew SeniorLife Institute for Aging Research, Boston, Massachusetts; §Department of Public Health Sciences, PennState College of Medicine, Hershey, Pennsylvania; Division of General Internal Medicine, MD Anderson Cancer Center, University of Texas, Houston, Texas; #Division of General Internal Medicine and Geriatrics, and **Center for Aging Research, Regenstrief Institute Inc., Indiana University, Indianapolis, Indiana.
    Search for more papers by this author
  • Holly M. Holmes MD,

    1. From the *Division of Geriatric Medicine, University of Massachusetts Medical School, Worcester, Massachusetts; University of New England College of Osteopathic Medicine, Biddeford, Maine; Hebrew SeniorLife Institute for Aging Research, Boston, Massachusetts; §Department of Public Health Sciences, PennState College of Medicine, Hershey, Pennsylvania; Division of General Internal Medicine, MD Anderson Cancer Center, University of Texas, Houston, Texas; #Division of General Internal Medicine and Geriatrics, and **Center for Aging Research, Regenstrief Institute Inc., Indiana University, Indianapolis, Indiana.
    Search for more papers by this author
  • Greg A. Sachs MD,

    1. From the *Division of Geriatric Medicine, University of Massachusetts Medical School, Worcester, Massachusetts; University of New England College of Osteopathic Medicine, Biddeford, Maine; Hebrew SeniorLife Institute for Aging Research, Boston, Massachusetts; §Department of Public Health Sciences, PennState College of Medicine, Hershey, Pennsylvania; Division of General Internal Medicine, MD Anderson Cancer Center, University of Texas, Houston, Texas; #Division of General Internal Medicine and Geriatrics, and **Center for Aging Research, Regenstrief Institute Inc., Indiana University, Indianapolis, Indiana.
    Search for more papers by this author
  • Susan L. Mitchell MD, MPH

    1. From the *Division of Geriatric Medicine, University of Massachusetts Medical School, Worcester, Massachusetts; University of New England College of Osteopathic Medicine, Biddeford, Maine; Hebrew SeniorLife Institute for Aging Research, Boston, Massachusetts; §Department of Public Health Sciences, PennState College of Medicine, Hershey, Pennsylvania; Division of General Internal Medicine, MD Anderson Cancer Center, University of Texas, Houston, Texas; #Division of General Internal Medicine and Geriatrics, and **Center for Aging Research, Regenstrief Institute Inc., Indiana University, Indianapolis, Indiana.
    Search for more papers by this author

Address correspondence to Jennifer Tjia, Division of Geriatric Medicine, University of Massachusetts Medical School, Biotech Four, 377 Plantation Street, Suite 315, Worcester, MA 01605. E-mail: jennifer.tjia@umassmed.edu

Abstract

OBJECTIVES: To describe the pattern and factors associated with daily medication use in nursing home (NH) residents with advanced dementia.

DESIGN: Prospective cohort study.

SETTING: Twenty-two Boston-area NHs.

PARTICIPANTS: NH residents with advanced dementia (N=323).

MEASUREMENTS: Data from residents' records were used to determine the number or daily medications, specific drugs prescribed, and use of drugs deemed “never appropriate” in patients with advanced dementia. Resident characteristics associated with the use of more daily medications and drugs deemed inappropriate were examined.

RESULTS: Residents were prescribed a mean of 5.9 ± 3.0 daily medications, and 37.5% received at least one medication considered “never appropriate” in advanced dementia. Acetylcholinesterase inhibitors (15.8%) and lipid-lowering agents (12.1%) were the most common inappropriate drugs. Twenty-eight percent of residents took antipsychotics daily. Modest reductions in most daily medications occurred only during the last week of life. Factors independently associated with taking more daily medications included older age, male sex, non-white race, dementia not due to Alzheimer's disease, better cognition, cardiovascular disease, acute illness, and hospice referral. Factors independently associated with greater likelihood of taking inappropriate medications included being male, shorter NH stay, better functional status, and diabetes mellitus, whereas a do-not-hospitalize order was associated with a lower likelihood.

CONCLUSION: Questionably beneficial medications are common in advanced dementia, even as death approaches. Several characteristics can help identify residents at risk for greater medication burden. Medication use in advanced dementia should be tailored to the goals of care.

Ancillary