This paper was presented in poster form at the 2010 Claude D. Pepper Older Americans Independence Center Annual Meeting in Bethesda, MD. It also was presented in abstract and poster form at the 2010 American Geriatrics Society Annual Scientific Meeting in Orlando, FL.
Association Between Combined Interleukin-6 and C-Reactive Protein Levels and Pulmonary Function in Older Women: Results from the Women's Health and Aging Studies I and II
Article first published online: 13 JAN 2011
© 2011, Copyright the Authors. Journal compilation © 2011, The American Geriatrics Society
Journal of the American Geriatrics Society
Volume 59, Issue 1, pages 113–119, January 2011
How to Cite
Chang, S. S., Vaz Fragoso, C. A., Van Ness, P. H., Fried, L. P. and Tinetti, M. E. (2011), Association Between Combined Interleukin-6 and C-Reactive Protein Levels and Pulmonary Function in Older Women: Results from the Women's Health and Aging Studies I and II. Journal of the American Geriatrics Society, 59: 113–119. doi: 10.1111/j.1532-5415.2010.03203.x
- Issue published online: 13 JAN 2011
- Article first published online: 13 JAN 2011
Vol. 59, Issue 4, 778, Article first published online: 14 APR 2011
- pulmonary function;
- older women
OBJECTIVES: To determine whether combined higher interleukin-6 (IL-6) and C-reactive protein (CRP) levels are associated with lower pulmonary function levels in older women, accounting for chronic inflammatory diseases, physical function, and other factors associated with inflammation.
DESIGN: Cross-sectional study using data from two prospective cohorts.
SETTING: Baltimore, Maryland.
PARTICIPANTS: Eight hundred forty disabled and 332 higher-functioning community-dwelling women aged 65 and older from the Women's Health and Aging Studies (WHAS) I and II, respectively.
MEASUREMENTS: IL-6 and CRP, combined according to their tertile concentrations, and pulmonary function measures, assessed according to forced expiratory volume in 1 second (FEV1) and forced vital capacity (FVC).
RESULTS: In WHAS I and II, similar dose-response trends were observed between combined higher IL-6 and CRP levels and lower pulmonary function levels. In WHAS I (disabled women), the combined highest IL-6 and CRP levels were associated with the lowest levels of FEV1 (mean 137.0 mL, 95% confidence interval (CI)=128.4–145.7 mL) and FVC (mean 191.7 mL, 95% CI=180.4–202.9 mL). Similarly, in WHAS II (higher-functioning women), the combined highest IL-6 and CRP levels were associated with the lowest levels of FEV1 (mean 158.3 mL, 95% CI=146.3–170.4 mL) and FVC (mean 224.2 mL, 95% CI=209.9–238.5 mL).
CONCLUSION: Combined elevations in IL-6 and CRP were associated with the lowest pulmonary function levels in older women. These findings suggest that high IL-6 and CRP levels may be an indication of prevalent impaired pulmonary function. Future studies should determine whether measurement of IL-6 and CRP could enhance current methods of monitoring respiratory diseases beyond that provided by pulmonary function measures.