Related paper presentations: Association Between Inflammatory Markers and Depressive Symptoms in Older Adults after Hip Fracture: The Baltimore Hip Studies, as part of the Baltimore Hip Studies Symposium at the 61st Annual Meeting of the Gerontological Society of America, November 2008.
Inflammatory Cytokine Levels and Depressive Symptoms in Older Women in the Year After Hip Fracture: Findings from the Baltimore Hip Studies
Article first published online: 20 DEC 2011
© 2011, Copyright the Authors Journal compilation © 2011, The American Geriatrics Society
Journal of the American Geriatrics Society
Volume 59, Issue 12, pages 2249–2255, December 2011
How to Cite
Matheny, M. E., Miller, R. R., Shardell, M. D., Hawkes, W. G., Lenze, E. J., Magaziner, J. and Orwig, D. L. (2011), Inflammatory Cytokine Levels and Depressive Symptoms in Older Women in the Year After Hip Fracture: Findings from the Baltimore Hip Studies. Journal of the American Geriatrics Society, 59: 2249–2255. doi: 10.1111/j.1532-5415.2011.03727.x
- Issue published online: 20 DEC 2011
- Article first published online: 20 DEC 2011
- National Institutes of Health. Grant Numbers: R37 AG09901, R01 AG029315, R01 AG18668, K23 AG027746, T32 AG00262, P30 AG028747
- Eli Lilly
- Johnson & Johnson
- depressive symptoms;
- hip fracture;
- Geriatric Depression Scale;
To determine whether interleukin (IL)-6 or soluble tumor necrosis factor alpha receptor 1 (sTNF-αR1) is associated with depressive symptoms in the year after hip fracture.
Three Baltimore-area hospitals.
Community-dwelling women aged 65 and older admitted with a new, nonpathological fracture of the proximal femur (N = 134).
Two, 6, and 12 months after fracture, serum was analyzed for IL-6 and sTNF-αR1, and depressive symptoms were measured using the 15-item Geriatric Depression Scale (GDS). Generalized estimating equations were used to model the longitudinal relationship between IL-6, sTNF-αR1, and GDS score. Whether lower extremity function, as measured according to the Lower Extremity Gain Scale (LEGS), explained the relationship between IL-6, sTNF-αR1, and GDS score was also examined.
Participants in the highest categories of IL-6 (≥5.14 pg/mL) and sTNF-αR1 (≥2,421 pg/mL) had the highest GDS scores in the year after fracture (P = .09 for both). Twelve months after fracture, those in the highest IL-6 and sTNF-αR1 categories had GDS scores that were on average 1.9 (95% confidence interval (CI) = 0.4–3.4, P = .01) and 1.4 (95% CI = −0.1–3.0, P = .07) points higher than those in the lowest category, respectively. Adjusting for LEGS score, the mean difference in GDS scores for highest versus lowest IL-6 categories was 1.6 (95% CI = 0.2–3.0, P = .02) points at 12 months.
Results from these exploratory analyses support a role for inflammation in the pathophysiology of depressive symptoms after hip fracture. Depressive symptoms in the context of high cytokine levels may represent a sickness syndrome that is chronic in some individuals. Further research should establish the cause and effect of this relationship, as well as long-term correlates.