Lifestyle and the Risk of Dementia in Japanese-American Men
Article first published online: 28 DEC 2011
© 2011, Copyright the Authors Journal compilation © 2011, The American Geriatrics Society
Journal of the American Geriatrics Society
Volume 60, Issue 1, pages 118–123, January 2012
How to Cite
Gelber, R. P., Petrovitch, H., Masaki, K. H., Abbott, R. D., Ross, G. W., Launer, L. J. and White, L. R. (2012), Lifestyle and the Risk of Dementia in Japanese-American Men. Journal of the American Geriatrics Society, 60: 118–123. doi: 10.1111/j.1532-5415.2011.03768.x
- Issue published online: 12 JAN 2012
- Article first published online: 28 DEC 2011
- National Institute on Aging. Grant Number: N01-HC-05102
- National Heart, Lung, and Blood Institute
- Research and Development
- Medical Research Service
- Department of Veterans Affairs
To determine whether adhering to a healthy lifestyle in midlife may reduce the risk of dementia.
Case–control study nested in a prospective cohort.
The Honolulu-Asia Aging Study, Oahu, Hawaii.
Three thousand four hundred sixty-eight Japanese-American men (mean age 52 in 1965–1968) examined for dementia 25 years later.
Men at low risk were defined as those with the following midlife characteristics: nonsmoking, body mass index (BMI) less than 25.0 kg/m2, physically active, and having a healthy diet (based on alcohol, dairy, meat, fish, fruits, vegetables, cereals, and ratio of monounsaturated to saturated fat). Logistic regression was used to calculate odds ratios (ORs) and 95% confidence intervals (CIs) for developing overall dementia, Alzheimer's disease (AD), and vascular dementia (VaD), adjusting for potential confounders.
Dementia was diagnosed in 6.4% of men (52.5% with AD, 35.0% with VaD). Examining the risk factors individually, BMI was most strongly associated with greater risk of overall dementia (OR = 1.87, 95% CI = 1.26–2.77; BMI > 25.0 vs <22.6 kg/m2). All of the individual risk factors except diet score were significantly associated with VaD, whereas none were significantly associated with AD alone. Men with all four low-risk characteristics (7.2% of the cohort) had the lowest OR for overall dementia (OR = 0.36, 95% CI = 0.15–0.84). There were no significant associations between the combined low-risk characteristics and the risk of AD alone.
Among Japanese-American men, having a healthy lifestyle in midlife is associated with a lower risk of dementia in late life.