Metformin, Other Antidiabetic Drugs, and Risk of Alzheimer's Disease: A Population-Based Case–Control Study
Article first published online: 28 MAR 2012
© 2012, Copyright the Authors Journal compilation © 2012, The American Geriatrics Society
Journal of the American Geriatrics Society
Volume 60, Issue 5, pages 916–921, May 2012
How to Cite
Imfeld, P., Bodmer, M., Jick, S. S. and Meier, C. R. (2012), Metformin, Other Antidiabetic Drugs, and Risk of Alzheimer's Disease: A Population-Based Case–Control Study. Journal of the American Geriatrics Society, 60: 916–921. doi: 10.1111/j.1532-5415.2012.03916.x
- Issue published online: 15 MAY 2012
- Article first published online: 28 MAR 2012
- Alzheimer's disease;
- antidiabetic drugs
To explore the risk of developing Alzheimer's disease (AD) in individuals with diabetes mellitus treated with metformin or other antidiabetic drugs.
The United Kingdom–based General Practice Research Database (GPRD), a well-established primary care database.
Seven thousand eighty-six individuals aged 65 and older with an incident diagnosis of AD identified between 1998 and 2008 and the same number of matched controls without dementia. Matching criteria were age, sex, general practice, calendar time, and years of history in the database.
Comparison of previous use of metformin or other antidiabetic drugs between cases and controls and calculation of corresponding odds ratios (ORs) with 95% confidence intervals (CIs), using conditional logistic regression. Risk estimates were stratified according to duration of use and adjusted for potential confounders.
As compared with nonusers, long-term users of 60 or more metformin prescriptions were at greater risk of developing AD (adjusted OR (AOR) = 1.71, 95% CI = 1.12–2.60), but there was no consistent trend with increasing number of prescriptions. Long-term use of other antidiabetic drugs such as sulfonylureas (AOR = 1.01, 95% CI = 0.72–1.42), thiazolidinediones (AOR = 0.87, 95% CI = 0.31–2.40), or insulin (AOR = 1.01, 95% CI = 0.58–1.73) was not related to an altered risk of developing AD.
Long-term use of sulfonylureas, thiazolidinediones, or insulin was not associated with an altered risk of developing AD. There was a suggestion of a slightly higher risk of AD in long-term users of metformin.