Data were presented, in part, at the Gerontological Society of America 62nd Annual Scientific Meeting, Atlanta, Georgia, November 18–22, 2009.
Antidepressant Use, Depressive Symptoms, and Incident Frailty in Women Aged 65 and Older from the Women's Health Initiative Observational Study
Version of Record online: 9 MAY 2012
© 2012, Copyright the Authors Journal compilation © 2012, The American Geriatrics Society
Journal of the American Geriatrics Society
Volume 60, Issue 5, pages 854–861, May 2012
How to Cite
Lakey, S. L., LaCroix, A. Z., Gray, S. L., Borson, S., Williams, C. D., Calhoun, D., Goveas, J. S., Smoller, J. W., Ockene, J. K., Masaki, K. H., Coday, M., Rosal, M. C. and Woods, N. F. (2012), Antidepressant Use, Depressive Symptoms, and Incident Frailty in Women Aged 65 and Older from the Women's Health Initiative Observational Study. Journal of the American Geriatrics Society, 60: 854–861. doi: 10.1111/j.1532-5415.2012.03940.x
- Issue online: 15 MAY 2012
- Version of Record online: 9 MAY 2012
- National Heart, Lung, and Blood Institute
- National Institutes of Health
- U.S. Department of Health and Human Services. Grant Numbers: N01WH22110, 42107–26, 42129–32, 44221, T32 AG027677, 24152, 32100–2, 32105–6, 32108–9, 32111–13, 32115, 32118–32119, 32122
- National Institute of Aging
- antidepressant use;
- Women's Health Initiative
To examine the associations between depressive symptoms, antidepressant use, and duration of use with incident frailty 3 years later in nonfrail women aged 65 and older.
Secondary analysis of the Women's Health Initiative Observational Study (WHI-OS), a prospective cohort study.
WHI-OS was conducted in 40 U.S. clinical centers.
Women aged 65 to 79, not frail at baseline.
Antidepressant use was assessed through medication container inspection at baseline. Four groups were created according to baseline use and Burnam depression screen (range 0–1, 0.06 cutoff): antidepressant nonusers without depressive symptoms (reference group), antidepressant nonusers with depressive symptoms, antidepressant users without depressive symptoms, and antidepressant users with depressive symptoms. Frailty components included slowness or weakness, exhaustion, low physical activity, and unintended weight loss, ascertained through self-report and physical measurements at baseline and Year 3.
Of 27,652 women at baseline, 1,350 (4.9%) were antidepressant users and 1,794 (6.5%) were categorized as depressed. At Year 3, 4,125 (14.9%) were frail. All groups had a greater risk of incident frailty than the reference group. Odds ratios (ORs) ranged from 1.73 (95% confidence interval (CI) = 1.41–2.12) in antidepressant users who were not depressed to 3.63 in antidepressant users who were depressed (95% CI = 2.37–5.55). All durations of use were associated with incident frailty (<1 year OR = 1.95, 95% CI = 1.41–2.68; 1–3 years OR = 1.99, 95% CI = 1.45–2.74; >3 years OR = 1.60, 95% CI = 1.20–2.14).
In older adult women, depressive symptoms and antidepressant use were associated with frailty after 3 years of follow-up.