Relationship Between Vitamin B12 and Sensory and Motor Peripheral Nerve Function in Older Adults
Article first published online: 12 JUN 2012
© 2012, Copyright the Authors Journal compilation © 2012, The American Geriatrics Society
Journal of the American Geriatrics Society
Volume 60, Issue 6, pages 1057–1063, June 2012
How to Cite
Leishear, K., Boudreau, R. M., Studenski, S. A., Ferrucci, ., Rosano, C., de Rekeneire, N., Houston, D. K., Kritchevsky, S. B., Schwartz, A. V., Vinik, A. I., Hogervorst, E., Yaffe, K., Harris, T. B., Newman, A. B., Strotmeyer, E. S. and for the Health, Aging and Body Composition Study (2012), Relationship Between Vitamin B12 and Sensory and Motor Peripheral Nerve Function in Older Adults. Journal of the American Geriatrics Society, 60: 1057–1063. doi: 10.1111/j.1532-5415.2012.03998.x
- Issue published online: 12 JUN 2012
- Article first published online: 12 JUN 2012
- National Institute on Aging (NIA). Grant Numbers: N01-AG-6–2101, N01-AG-6–2103, N01-AG-6–2106
- NIA Intramural Research Program of the National Institutes of Health. Grant Number: R01-AG 028050
- National Institute of Nursing Research. Grant Number: R01-NR012459
- University of Pittsburgh Claude D. Pepper Older Americans Independence Center. Grant Number: P30-AG024827
- NIA. Grant Number: T32-AG-000181
- low B12;
- deficient B12;
- sensory peripheral nerve function;
- motor nerve conduction;
- older adults
To examine whether deficient B12 status or low serum B12 levels are associated with worse sensory and motor peripheral nerve function in older adults.
Health, Aging and Body Composition Study.
Two thousand two hundred and eighty-seven adults aged 72 to 83 (mean 76.5 ± 2.9; 51.4% female; 38.3% black).
Low serum B12 was defined as serum B12 less than 260 pmol/L, and deficient B12 status was defined as B12 less than 260 pmol/L, methylmalonic acid (MMA) greater than 271 nmol/L, and MMA greater than 2-methylcitrate. Peripheral nerve function was assessed according to peroneal nerve conduction amplitude and velocity (NCV) (motor), 1.4 g/10 g monofilament detection, average vibration threshold detection, and peripheral neuropathy symptoms (numbness, aching or burning pain, or both) (sensory).
B12-deficient status was found in 7.0% of participants, and an additional 10.1% had low serum B12 levels. B12 deficient status was associated with greater insensitivity to light (1.4 g) touch (odds ratio = 1.50, 95% confidence interval = 1.06–2.13) and worse NCV (42.3 vs 43.5 m/s) (β = −1.16, P = .01) after multivariable adjustment for demographics, lifestyle factors, and health conditions. Associations were consistent for the alternative definition using low serum B12 only. No significant associations were found for deficient B12 status or the alternative low serum B12 definition and vibration detection, nerve conduction amplitude, or peripheral neuropathy symptoms.
Poor B12 (deficient B12 status and low serum B12) is associated with worse sensory and motor peripheral nerve function. Nerve function impairments may lead to physical function declines and disability in older adults, suggesting that prevention and treatment of low B12 levels may be important to evaluate.