Hyperglycemia and Incidence of Frailty and Lower Extremity Mobility Limitations in Older Women
Article first published online: 10 AUG 2012
© 2012, Copyright the Authors Journal compilation © 2012, The American Geriatrics Society
Journal of the American Geriatrics Society
Volume 60, Issue 9, pages 1701–1707, September 2012
How to Cite
J Am Geriatr Soc 60:1701–1707, 2012.
- Issue published online: 17 SEP 2012
- Article first published online: 10 AUG 2012
- Johns Hopkins Older Americans Independence Center. Grant Number: P30-AG021334
- National Institute on Aging. Grant Numbers: R37AG19905, R01AG021493
- Veterans Affairs Ann Arbor Geriatrics Research, Education and Clinical Center
To determine the degree to which hyperglycemia predicts the development of frailty and lower extremity mobility limitations.
Secondary data analysis of longitudinal data collected in a prospective cohort study.
Three hundred twenty-nine women from the Women's Health and Aging Study II aged 70 to 79 at baseline who had all variables needed for analysis.
Glycosylated hemoglobin (HbA1c) at baseline, categorized as less than 5.5%, 5.5% to 5.9%, 6.0% to 6.4%, 6.5% to 7.9%, and 8.0% and greater, was the independent variable. The incidence of frailty and lower extremity mobility limitations (based on self-reported walking difficulty, walking speed, and Short Performance Physical Battery score) was determined (follow-up ≈ 9 years). Frailty was assessed using the Cardiovascular Health Study criteria. Covariates included demographic characteristics, body mass index, interleukin-6 level, and clinical history of comorbidities. Statistical analyses included Kaplan–Meier survival curves and Cox regression models adjusted for important covariates.
In time-to-event analyses, HbA1c category was associated with incidence of walking difficulty (P = .049) and low physical performance (P = .001); association with incidence of frailty and low walking speed had a trend toward significance (both P = .10). In regression models adjusted for demographic characteristics, HbA1c of 8.0% or greater (vs < 5.5%) was associated with an approximately three-times greater risk of incident frailty and three to five times greater risk of lower extremity mobility limitations (all P < .05). In fully adjusted models, HbA1c of 8.0% or greater (vs < 5.5%) was associated with incident frailty (hazard ratio (HR) = 3.33, 95% confidence interval (CI) = 1.24–8.93), walking difficulty (HR = 3.47, 95% CI = 1.26–9.55), low walking speed (HR = 2.82, 95% CI = 1.19–6.71), and low physical performance (HR = 3.60, 95% CI = 1.52–8.53).
Hyperglycemia is associated with the development of frailty and lower extremity mobility limitations in older women. Future studies should identify mediators of these relationships.