Serum Albumin in Relation to Change in Muscle Mass, Muscle Strength, and Muscle Power in Older Men
Article first published online: 20 AUG 2012
© 2012, Copyright the Authors Journal compilation © 2012, The American Geriatrics Society
Journal of the American Geriatrics Society
Volume 60, Issue 9, pages 1663–1672, September 2012
How to Cite
J Am Geriatr Soc 60:1663–1672, 2012.
- Issue published online: 17 SEP 2012
- Article first published online: 20 AUG 2012
- National Institutes of Health. Grant Numbers: U01 AG027810, U01 AR45647
- Shriners Hospitals for Children
- The National Institute of Arthritis and Musculoskeletal and Skin Diseases
- The National Institute on Aging, the National Center for Research Resources
- NIH Roadmap for Medical Research
- body composition;
To investigate the relationship between serum albumin and change in muscle mass, grip strength, and leg power.
Six U.S. academic medical centers.
Community-dwelling men aged 65 and older participating in the Osteoporotic Fractures in Men (MrOS) Study.
Serum albumin was measured at baseline in 5,534 participants. Baseline serum albumin was examined in relation to change in appendicular skeletal muscle (ASM) mass, grip strength, and leg power after 2 and 4.6 years. Two-year change in serum albumin was examined with respect to simultaneous change in these outcomes in 1,267 participants.
Baseline serum albumin <40 g/L was not associated with 2- or 4.6-year change in ASM mass, grip strength, or leg power before or after adjustment for confounders. There was no association between serum albumin change and change in grip strength. A statistically significant trend was observed between serum albumin change and change in ASM mass, but there was substantial overlap across confidence intervals (CIs). Participants with a marked decrease (>3 g/L) and mild decrease (1–2 g/L) in serum albumin over 2 years exhibited a modest change of −8.9 W (95% CI = −25.6 to −7.8 W) and −6.3 W (95% CI = −21.2 to −8.5 W) of leg power, respectively (P for trend = .02), compared with those with no decrease in albumin concentration.
Serum albumin demonstrated modest and inconsistent trends with loss of muscle mass and function. Low serum albumin within the normal range is not a risk factor for this process in elderly men.