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Serum Albumin in Relation to Change in Muscle Mass, Muscle Strength, and Muscle Power in Older Men

Authors

  • Caryn K. Snyder MPH,

    1. Department of Public Health and Preventive Medicine, Oregon Health and Science University, Portland, Oregon
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  • Jodi A. Lapidus PhD,

    1. Division of Biostatistics, Oregon Health & Science University, Portland, Oregon
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  • Peggy M. Cawthon PhD, MPH,

    1. California Pacific Medical Center Research Institute, San Francisco, California
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  • Thuy-Tien L. Dam MD,

    1. Division of Geriatric Medicine and Aging, Department of Medicine, College of Physicians and Surgeons, Columbia University, NewYork, NewYork
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  • Lynn Y. Sakai PhD,

    1. Portland Shriners Research Center, Shriners Hospitals for Children, Portland, Oregon
    2. Department of Biochemistry and Molecular Biology, Oregon Health and Science University, Portland, Oregon
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  • Lynn M. Marshall ScD,

    Corresponding author
    1. Bone and Mineral Unit, Oregon Health and Science University, Portland, Oregon
    2. Department of Orthopaedics and Rehabilitation, Oregon Health & Science University, Portland, Oregon
    • Department of Public Health and Preventive Medicine, Oregon Health and Science University, Portland, Oregon
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  • the Osteoporotic Fractures in Men (MrOS) Research Group


Address correspondence to Lynn M. Marshall, Department of Orthopaedics and Rehabilitation, Oregon Health & Science University, 3181 SW Sam Jackson Park Rd, Mailcode OP31, Portland, OR 97239. E-mail: marshaly@ohsu.edu

Abstract

Objectives

To investigate the relationship between serum albumin and change in muscle mass, grip strength, and leg power.

Design

Prospective cohort.

Setting

Six U.S. academic medical centers.

Participants

Community-dwelling men aged 65 and older participating in the Osteoporotic Fractures in Men (MrOS) Study.

Measurements

Serum albumin was measured at baseline in 5,534 participants. Baseline serum albumin was examined in relation to change in appendicular skeletal muscle (ASM) mass, grip strength, and leg power after 2 and 4.6 years. Two-year change in serum albumin was examined with respect to simultaneous change in these outcomes in 1,267 participants.

Results

Baseline serum albumin <40 g/L was not associated with 2- or 4.6-year change in ASM mass, grip strength, or leg power before or after adjustment for confounders. There was no association between serum albumin change and change in grip strength. A statistically significant trend was observed between serum albumin change and change in ASM mass, but there was substantial overlap across confidence intervals (CIs). Participants with a marked decrease (>3 g/L) and mild decrease (1–2 g/L) in serum albumin over 2 years exhibited a modest change of −8.9 W (95% CI = −25.6 to −7.8 W) and −6.3 W (95% CI = −21.2 to −8.5 W) of leg power, respectively (P for trend = .02), compared with those with no decrease in albumin concentration.

Conclusion

Serum albumin demonstrated modest and inconsistent trends with loss of muscle mass and function. Low serum albumin within the normal range is not a risk factor for this process in elderly men.

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