Is Frailty a Prodromal Stage of Vascular Dementia? Results From the Three-City Study
Version of Record online: 17 SEP 2012
© 2012, Copyright the Authors Journal compilation © 2012, The American Geriatrics Society
Journal of the American Geriatrics Society
Volume 60, Issue 9, pages 1708–1712, September 2012
How to Cite
J Am Geriatr Soc 60:1708–1712, 2012.
- Issue online: 17 SEP 2012
- Version of Record online: 17 SEP 2012
- Caisse Nationale Maladie des Travailleurs Salariés. Grant Number: Institut de la Longévité
- Asociación Nacional de Universidades e Instituciones de Educación Superior
- CONACyT in Mexico. Grant Number: Institut de la Longévité
- Direction Générale de la Santé
- Mutuelle Générale de l’Éducation Nationale
- Institut de la Longévité
- Regional Councils of Aquitaine and Bourgogne
- Fondation de France
- Ministry of Research-INSERM Programme Cohortes et collections de données biologiques
- Bourse ECOS
- Ministère des Affaires Étrangères in France and the Secretaría de Educación Pública
- vascular dementia;
- cognitive impairment;
- cohort study
To investigate the relationship between frailty and incident vascular dementia (VaD).
Seven-year longitudinal study.
Three-City Study, a French prospective study designed to evaluate the risk of dementia and cognitive decline attributable to vascular risk factors.
Five thousand four hundred eighty community-dwelling persons aged 65 to 95.
An expert committee established a clinical diagnosis of VaD. Frailty was defined as having at least three of the following criteria: weight loss, weakness, exhaustion, slowness, and low physical activity. Participants with prior stroke or prevalent dementia at baseline were excluded from analyses. Multivariate models were used to evaluate the relationship between frailty and incident VaD.
At baseline, 6.5% of participants were classified as frail. After 7 years of follow-up, 54 persons were diagnosed with VaD, seven of whom where frail. In the proportional hazards models, frailty was marginally associated with greater risk of all types of dementia and was not associated with incident Alzheimer's disease, but frailty status was independently associated with incident VaD.
Frailty is a major risk factor for incident VaD, so its identification could contribute to better estimates of the risk of VaD in elderly adults.