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Isobutyl 2-cyanoacrylate was used to reattach partial-thickness cortical bone fragments from the femur in rabbits. Stability, apposition, callus formation, and inflammation around the fragments were evaluated at 2, 4, 8, and 12 weeks.

All glued bone fragments were stable, compared with 85% of controls. Good apposition was achieved in 95% of the glued bone fragments, compared with 19% of the controls. Analysis of the mean scores for callus formation revealed a significant difference only in the 8 week survival group.

Bony union was noted in 20 of 21 of the glued fragments. No evidence of inflammation was seen around the glue, and viable bone was seen adjacent to the adhesive in many sections. In control legs, 13 fragments had healed by osseous union, two by fibrous union, and in six the chip had resorbed.