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Two hundred and thirteen bovine and 115 equine long bone fractures presented for treatment to the Western College of Veterinary Medicine were reviewed. Based on the number of patients presented, cattle had a significantly (p < 0.01) higher survival rate than horses. In horses, the third metatarsal bone was most frequently presented for fracture treatment, but in cattle, the femur was most commonly affected. There was no significant difference (p > 0.05) in the treatment success rates when comparing the bones affected, methods of treatment used, duration between the fracture occurrence and presentation for repair, distance traveled prior to hospitalization, type of limb support during transportation, or medication given prior to hospitalization. Horses between 3 months and 2 years of age had a significantly (p < 0.05) lower survival rate than those in other age groups. Compared to open and comminuted fractures, a significantly (p < 0.01) greater number of simple fractures were selected for treatment in horses. Based on the cases presented, the survival rate of the horses with simple fractures is higher (p < 0.05). However, there was no significant difference between the survival rates of horses or cattle when simple, open, comminuted, and open plus comminuted fractures were treated. There were significantly (p < 0.001) more open fractures in horses than in cattle. Postoperative complications occurred in 49% of the horses treated, and the enthanasia rate was significantly (p < 0.01) higher in horses with complications.