Effects of Xylazine and Ketamine on Epinephrine-lnduced Arrhythmia in the Dog

Authors

  • MOLLiE WRIGHT DVM, MS,

    Corresponding author
    1. Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, Colorado.
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  • R. B. HEATH DVS, MSC,

    1. Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, Colorado.
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  • W. E. WINGFIELD DVM

    1. Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, Colorado.
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Academy Animal Hospital, 201 E. 15th St. Joplin, MO 64801.

Abstract

Ten dogs were studied to determine the effects of xylazine, ketamine, and xylazine combined with ketamine on the dosage of epinephrine required to produce ventricular arrhythmia. Untreated dogs required an arrhythmogenic dose (AD) of 5.88 ± 2.85 μg/kg/min. The AD was 4.28 ± 3.25 μg/kg/min in xylazine-treated dogs, 3.05 ± 2.3 μg/kg/min in ketamine-treated dogs, and 2.96 ± 1.95 μg/kg/min in xylazine/ketamine-treated dogs. The latter two dosages were significantly less than that of the controls (p < 0.025). The duration of increased arrhythmogenicity was also examined. Four hours after drug administration, the AD for xylazine-treated dogs was decreased further to 3.87 ± 2.52 μg/kg/min (p < 0.05). Ketamine-treated dogs had returned partially to normal with an AD of 4.09 ± 3.09 μg/kg/min, as had xylazine/ketamine-treated dogs, at 4.22 ± 2.71 μg/kg/min.

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