Regional Perfusion of the Equine Carpus for Antibiotic Delivery
Article first published online: 28 JUN 2008
Volume 21, Issue 4, pages 279–285, July 1992
How to Cite
WHITEHAIR, K. J., BLEVINS, W. E., FESSLER, J. F., SICKLE, D. C. V., WHITE, M. R. and BILL, R. P. (1992), Regional Perfusion of the Equine Carpus for Antibiotic Delivery. Veterinary Surgery, 21: 279–285. doi: 10.1111/j.1532-950X.1992.tb00064.x
- Issue published online: 28 JUN 2008
- Article first published online: 28 JUN 2008
Regional perfusion of carpal tissues by forced intramedullary administration of fluids was evaluated in 10 horses. Results of subtraction radiography after perfusion with a contrast medium demonstrated that perfusate was delivered to the carpal tissues by the venous system. Perfused India ink was distributed uniformly in the antebrachiocarpal and middle carpal synovial membranes. Histologically, the ink was within the venules of the synovial villi. Immediately after perfusion with gentamicin sulfate (1g), the gentamicin concentrations in the synovial fluid and synovial membrane of the antebrachiocarpal joint were 349±240 μg/mL and 358±264 μg/g, respectively. When gentamicin concentrations in the synovial fluid of the antebrachiocarpal joint and serum were measured 0, 0.5, 1, 4, 8, 12, and 24 hours after carpal perfusion, the mean peak gentamicin concentration in the synovial fluid was 589 ± 429 μg/mL. At hour 24, the mean gentamicin concentration in the synovial fluid was 4.8 ± 2.0 μg/mL. The resulting peak gentamicin concentration in the serum was 23.7 ± 14.5 μg/mL immediately after the perfusion; it decreased below the desired trough level of 1 μg/mL between hours 4 and 8.