Thiamylal-Sparing Effect of Midazolam for Canine Endotracheal Intubation A Clinical Study of 118 Dogs
Article first published online: 28 JUN 2008
Volume 22, Issue 1, pages 69–72, January 1993
How to Cite
GREENE, S. A., BENSON, G. J. and HARTSFIELD, S. M. (1993), Thiamylal-Sparing Effect of Midazolam for Canine Endotracheal Intubation A Clinical Study of 118 Dogs. Veterinary Surgery, 22: 69–72. doi: 10.1111/j.1532-950X.1993.tb00373.x
- Issue published online: 28 JUN 2008
- Article first published online: 28 JUN 2008
One hundred eighteen dogs were studied at three veterinary teaching hospitals after the administration of midazolam (0.1 mg/kg, intravenously [IV]) or a placebo. Midazolam and placebo treatments were randomized and blinded to the investigators. The dose of thiamylal required for tracheal intubation 3 to 5 minutes after midazolam or placebo was calculated. The dose of thiamylal at the three hospitals was 10.6,9.8, and 10.1 mg/kg IV after midazolam, and 12.1,11.2, and 11.6 mg/kg IV after placebo. Pooled data from the three hospitals yielded a significant (p < .001) decrease in mean IV thiamylal dose after midazolam (10.2 mg/kg) compared with placebo (11.6 mg/kg). Overall, there was a 12% decrease in the dose of thiamylal required for tracheal intubation after midazolam compared to that after the placebo. The thiamylal dose was significantly (p < .001) decreased after midazolam compared with placebo for dogs weighing more than 15 kg but not for dogs weighing less than 15 kg.