Hemodynamic Effects of Interpleural Lidocaine and Bupivacaine Combination in Anesthetized Dogs with and Without an Open Pericardium

Authors

  • FABRICE BERNARD DVM,

    1. From 1Clinique Veterinaire, Neuilly sur Seine, France, the Regional Veterinary Referral Center, Springfield, VA, and the Department of Clinical Sciences, College of Veterinary Medicine & Biomedical Sciences, Colorado State University, Fort Collins, CO
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  • 1 SIMON T. KUDNIG BVSc, MVS, MS, FACVSc, Diplomate ACVS,

    1. From 1Clinique Veterinaire, Neuilly sur Seine, France, the Regional Veterinary Referral Center, Springfield, VA, and the Department of Clinical Sciences, College of Veterinary Medicine & Biomedical Sciences, Colorado State University, Fort Collins, CO
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  • and 1 ERIC MONNET DVM, PhD, Diplomate ACVS & ECVS 1

    1. From 1Clinique Veterinaire, Neuilly sur Seine, France, the Regional Veterinary Referral Center, Springfield, VA, and the Department of Clinical Sciences, College of Veterinary Medicine & Biomedical Sciences, Colorado State University, Fort Collins, CO
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  • Supported by the Surgeon-In-Training Research Grant from the American College of Veterinary Surgeons.

  • Presented at the 14th Annual European College of Veterinary Surgeons Scientific Meeting, Lyon, France, July 7, 2005.

Address reprint request to Dr. Eric Monnet, James L. Voss Veterinary Teaching Hospital, Colorado State University, 300 West Drake Road, Fort Collins, CO 80523-1620. E-mail: Eric.Monnet@colostate.edu.

Abstract

Objective— To identify dysrhythmias and hemodynamic changes after lidocaine and bupivacaine infusion into the interpleural space with an open pericardium.

Study Design— Experimental study.

Animals— Six adult dogs.

Methods— Systemic arterial pressure and electrocardiogram were recorded. A 7.5 Fr Swan-Ganz catheter was advanced to the level of the main pulmonary artery to record pulmonary arterial pressure. Cardiac output was measured by a thermodilution technique. A pericardial window (PW) was performed in 3 dogs using thoracoscopy. Hemodynamic variables were recorded before and 15 minutes after injection of lidocaine (1.5 mg/kg) and bupivacaine (1.5 mg/kg) into the pleural space in the control group and in the pericardial space for the PW group. A randomized-block ANOVA for repeated measures was used to evaluate the effect of local anesthetic administration on hemodynamic and electrophysiologic variables in dogs with a pericardectomy.

Results— Each dog maintained sinus rhythm. Infusion of local anesthetic induced a significant increase in right ventricular diastolic pressure (P=.002) and a significant decrease in stroke volume (P=.047) in both groups; however, the effects were not significantly different between groups.

Conclusions— Infusion of lidocaine and bupivacaine, either intrapleural or in the pericardial space, had a mild detrimental effect on cardiac output.

Clinical Relevance— Intrapleural administration of lidocaine and bupivacaine at a therapeutic dose can be used safely in healthy dogs with a pericardectomy.

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