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Objective— To report treatment and wound healing after radical surgical mass excision in the equine buccal region.

Study Design— Clinical case reports.

Animals— An 11-year-old Warmblood gelding and a 9-year-old Norwegian Trotter gelding.

Methods— Large tumoral masses were removed from the buccal region by radical electrosurgery, creating large defects into the oral cavity. Wound ultimately healed by second intention.

Results— Buccal defects in both horses healed well by second intention without tumor recurrence.

Conclusions— Locally invasive tumors involving the cheek region of the horse can be successfully treated by radical electroexcision alone, creating transmural defects up to 14 cm length × 8 cm height.

Clinical Relevance— Large transmural defects in the cheek region of the horse, formed by radical surgery can heal satisfactorily by second intention healing without undue discomfort to the patient or major complications.