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Evaluation of Pentosan Polysulfate Sodium in the Postoperative Recovery from Cranial Cruciate Injury in Dogs: A Randomized, Placebo-Controlled Clinical Trial

Authors


  • Presented in part at the 2005 Veterinary Orthopedic Society Meeting, March 6–12, 2005 Snowmass, CO.

  • Funding for this project was provided in part by Biopharm Australia Pty Ltd.

  • Dr. Bergh's current address is The Ohio State University College of Veterinary Medicine, Columbus, OH.

Address reprint requests to Dr. Budsberg, Department of Small Animal Medicine and Surgery, University of Georgia College of Veterinary Medicine, 501 DW Brooks Dr, University of Georgia, Athens, GA 30602. E-mail: Budsberg@vet.uga.edu.

Abstract

Objective— To evaluate the efficacy of pentosan polysulfate (PPS) for improving the recovery period and mitigate the progression of osteoarthritis (OA) of the canine stifle after extracapsular stabilization of cranial cruciate ligament (CCL) injuries.

Study Design— Randomized, blinded, placebo-controlled clinical trial.

Animals— Dogs (n=40) with unilateral CCL instability.

Methods— Each dog had an extracapsular stabilization of the stifle with or without partial meniscectomy. Dogs were divided into 4 groups based on preoperative radiographic assessment and whether a partial meniscectomy was performed. Dogs were randomly assigned to either (3 mg/kg) PPS or placebo treatment in each group, and then injected subcutaneously weekly for 4 weeks. Lameness, radiographic changes, biological marker concentration in blood and urine, and ground reaction forces (GRFs) were collected preoperatively, and at 6, 12, 24, and 48 weeks. Data were analyzed within and between groups using repeated measures ANOVA; P<.05 was considered significant.

Results— No adverse reactions to PPS were reported. Thirty-nine dogs completed a minimum of 24-weeks follow-up and 33 dogs completed 48 weeks. All dogs clinically improved after surgery without differences in lameness score, vertical GRFs, or radiographic progression. Grouped and evaluated only by initial radiographic score, PPS-treated dogs improved significantly faster in braking GRFs than placebo-treated dogs. In dogs with partial meniscectomies, urine deoxypyridinoline, and serum carboxy-propeptide of type II collagen were significantly increased at 6 weeks in placebo-treated dogs compared with PPS-treated dogs.

Conclusions— PPS administered after stabilization of the cruciate deficient stifle may prove to be a useful adjunctive treatment option, although further studies are necessary to substantiate this claim.

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