Biologic Behavior and Clinical Outcome of 25 Dogs with Canine Appendicular Chondrosarcoma Treated by Amputation: A Veterinary Society of Surgical Oncology Retrospective Study

Authors

  • JAMES P. FARESE DVM, Diplomate ACVS,

    1. College of Veterinary Medicine, University of Florida, Gainesville, FL
    2. Faculty of Veterinary Medicine, Utrecht University, The Netherlands; the Southwest Veterinary Oncology, Glendale, AZ
    3. Oregon Cancer Center for Animals, College of Veterinary Medicine, Oregon State University, Corvallis, OR
    4. the School of Veterinary Medicine, University of California–Davis, Davis, CA
    5. Alta Vista Animal Hospital, Ottawa, Canada
    6. Australian Animal Cancer Foundation, Brisbane Veterinary Specialist Centre, Brisbane, Australia
    7. Division of Biostatistics, College of Medicine, University of Florida, Gainesville, FL
    8. Animal Cancer Center, Colorado State University, Fort Collins, CO
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  • JOLLE KIRPENSTEIJN DVM, PhD, Diplomate ACVS, & ECVS,

    1. College of Veterinary Medicine, University of Florida, Gainesville, FL
    2. Faculty of Veterinary Medicine, Utrecht University, The Netherlands; the Southwest Veterinary Oncology, Glendale, AZ
    3. Oregon Cancer Center for Animals, College of Veterinary Medicine, Oregon State University, Corvallis, OR
    4. the School of Veterinary Medicine, University of California–Davis, Davis, CA
    5. Alta Vista Animal Hospital, Ottawa, Canada
    6. Australian Animal Cancer Foundation, Brisbane Veterinary Specialist Centre, Brisbane, Australia
    7. Division of Biostatistics, College of Medicine, University of Florida, Gainesville, FL
    8. Animal Cancer Center, Colorado State University, Fort Collins, CO
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  • MARJA KIK DVM, PhD, Diplomate Vet Path,

    1. College of Veterinary Medicine, University of Florida, Gainesville, FL
    2. Faculty of Veterinary Medicine, Utrecht University, The Netherlands; the Southwest Veterinary Oncology, Glendale, AZ
    3. Oregon Cancer Center for Animals, College of Veterinary Medicine, Oregon State University, Corvallis, OR
    4. the School of Veterinary Medicine, University of California–Davis, Davis, CA
    5. Alta Vista Animal Hospital, Ottawa, Canada
    6. Australian Animal Cancer Foundation, Brisbane Veterinary Specialist Centre, Brisbane, Australia
    7. Division of Biostatistics, College of Medicine, University of Florida, Gainesville, FL
    8. Animal Cancer Center, Colorado State University, Fort Collins, CO
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  • NICHOLAS J. BACON Vet MB, Diplomate ACVS, Diplomate ECVS,

    1. College of Veterinary Medicine, University of Florida, Gainesville, FL
    2. Faculty of Veterinary Medicine, Utrecht University, The Netherlands; the Southwest Veterinary Oncology, Glendale, AZ
    3. Oregon Cancer Center for Animals, College of Veterinary Medicine, Oregon State University, Corvallis, OR
    4. the School of Veterinary Medicine, University of California–Davis, Davis, CA
    5. Alta Vista Animal Hospital, Ottawa, Canada
    6. Australian Animal Cancer Foundation, Brisbane Veterinary Specialist Centre, Brisbane, Australia
    7. Division of Biostatistics, College of Medicine, University of Florida, Gainesville, FL
    8. Animal Cancer Center, Colorado State University, Fort Collins, CO
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  • SUZANNE SHELLY WALTMAN DVM, Diplomate ACVIM (Oncology),

    1. College of Veterinary Medicine, University of Florida, Gainesville, FL
    2. Faculty of Veterinary Medicine, Utrecht University, The Netherlands; the Southwest Veterinary Oncology, Glendale, AZ
    3. Oregon Cancer Center for Animals, College of Veterinary Medicine, Oregon State University, Corvallis, OR
    4. the School of Veterinary Medicine, University of California–Davis, Davis, CA
    5. Alta Vista Animal Hospital, Ottawa, Canada
    6. Australian Animal Cancer Foundation, Brisbane Veterinary Specialist Centre, Brisbane, Australia
    7. Division of Biostatistics, College of Medicine, University of Florida, Gainesville, FL
    8. Animal Cancer Center, Colorado State University, Fort Collins, CO
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  • BERNARD SEGUIN DVM Diplomate ACVS,

    1. College of Veterinary Medicine, University of Florida, Gainesville, FL
    2. Faculty of Veterinary Medicine, Utrecht University, The Netherlands; the Southwest Veterinary Oncology, Glendale, AZ
    3. Oregon Cancer Center for Animals, College of Veterinary Medicine, Oregon State University, Corvallis, OR
    4. the School of Veterinary Medicine, University of California–Davis, Davis, CA
    5. Alta Vista Animal Hospital, Ottawa, Canada
    6. Australian Animal Cancer Foundation, Brisbane Veterinary Specialist Centre, Brisbane, Australia
    7. Division of Biostatistics, College of Medicine, University of Florida, Gainesville, FL
    8. Animal Cancer Center, Colorado State University, Fort Collins, CO
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  • MICHAEL KENT DVM, Diplomate ACVIM (Oncology) & ACVR (Radiation Oncology),

    1. College of Veterinary Medicine, University of Florida, Gainesville, FL
    2. Faculty of Veterinary Medicine, Utrecht University, The Netherlands; the Southwest Veterinary Oncology, Glendale, AZ
    3. Oregon Cancer Center for Animals, College of Veterinary Medicine, Oregon State University, Corvallis, OR
    4. the School of Veterinary Medicine, University of California–Davis, Davis, CA
    5. Alta Vista Animal Hospital, Ottawa, Canada
    6. Australian Animal Cancer Foundation, Brisbane Veterinary Specialist Centre, Brisbane, Australia
    7. Division of Biostatistics, College of Medicine, University of Florida, Gainesville, FL
    8. Animal Cancer Center, Colorado State University, Fort Collins, CO
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  • JULIUS LIPTAK BVSc, MVetClinStud, FACVSc Diplomate ACVS & ECVS,

    1. College of Veterinary Medicine, University of Florida, Gainesville, FL
    2. Faculty of Veterinary Medicine, Utrecht University, The Netherlands; the Southwest Veterinary Oncology, Glendale, AZ
    3. Oregon Cancer Center for Animals, College of Veterinary Medicine, Oregon State University, Corvallis, OR
    4. the School of Veterinary Medicine, University of California–Davis, Davis, CA
    5. Alta Vista Animal Hospital, Ottawa, Canada
    6. Australian Animal Cancer Foundation, Brisbane Veterinary Specialist Centre, Brisbane, Australia
    7. Division of Biostatistics, College of Medicine, University of Florida, Gainesville, FL
    8. Animal Cancer Center, Colorado State University, Fort Collins, CO
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  • ROD STRAW BVSc, Diplomate ACVS, M(A)ACVSc,

    1. College of Veterinary Medicine, University of Florida, Gainesville, FL
    2. Faculty of Veterinary Medicine, Utrecht University, The Netherlands; the Southwest Veterinary Oncology, Glendale, AZ
    3. Oregon Cancer Center for Animals, College of Veterinary Medicine, Oregon State University, Corvallis, OR
    4. the School of Veterinary Medicine, University of California–Davis, Davis, CA
    5. Alta Vista Animal Hospital, Ottawa, Canada
    6. Australian Animal Cancer Foundation, Brisbane Veterinary Specialist Centre, Brisbane, Australia
    7. Division of Biostatistics, College of Medicine, University of Florida, Gainesville, FL
    8. Animal Cancer Center, Colorado State University, Fort Collins, CO
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  • MYRON N. CHANG PhD,

    1. College of Veterinary Medicine, University of Florida, Gainesville, FL
    2. Faculty of Veterinary Medicine, Utrecht University, The Netherlands; the Southwest Veterinary Oncology, Glendale, AZ
    3. Oregon Cancer Center for Animals, College of Veterinary Medicine, Oregon State University, Corvallis, OR
    4. the School of Veterinary Medicine, University of California–Davis, Davis, CA
    5. Alta Vista Animal Hospital, Ottawa, Canada
    6. Australian Animal Cancer Foundation, Brisbane Veterinary Specialist Centre, Brisbane, Australia
    7. Division of Biostatistics, College of Medicine, University of Florida, Gainesville, FL
    8. Animal Cancer Center, Colorado State University, Fort Collins, CO
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  • YANG JIANG,

    1. College of Veterinary Medicine, University of Florida, Gainesville, FL
    2. Faculty of Veterinary Medicine, Utrecht University, The Netherlands; the Southwest Veterinary Oncology, Glendale, AZ
    3. Oregon Cancer Center for Animals, College of Veterinary Medicine, Oregon State University, Corvallis, OR
    4. the School of Veterinary Medicine, University of California–Davis, Davis, CA
    5. Alta Vista Animal Hospital, Ottawa, Canada
    6. Australian Animal Cancer Foundation, Brisbane Veterinary Specialist Centre, Brisbane, Australia
    7. Division of Biostatistics, College of Medicine, University of Florida, Gainesville, FL
    8. Animal Cancer Center, Colorado State University, Fort Collins, CO
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  • STEPHEN J. WITHROW DVM, Diplomate ACVS & ACVIM (Oncology)

    1. College of Veterinary Medicine, University of Florida, Gainesville, FL
    2. Faculty of Veterinary Medicine, Utrecht University, The Netherlands; the Southwest Veterinary Oncology, Glendale, AZ
    3. Oregon Cancer Center for Animals, College of Veterinary Medicine, Oregon State University, Corvallis, OR
    4. the School of Veterinary Medicine, University of California–Davis, Davis, CA
    5. Alta Vista Animal Hospital, Ottawa, Canada
    6. Australian Animal Cancer Foundation, Brisbane Veterinary Specialist Centre, Brisbane, Australia
    7. Division of Biostatistics, College of Medicine, University of Florida, Gainesville, FL
    8. Animal Cancer Center, Colorado State University, Fort Collins, CO
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  • Work was performed at the University of Florida, College of Veterinary Medicine and Utrecht University, Utrecht, the Netherlands.
    Presented in part at the annual meeting of the Veterinary Cancer Society, Seattle, WA, October 18–20, 2008.

Corresponding author: James P. Farese, DVM, Diplomate ACVS, Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, 2015 SW 16th Ave. FL 32610-0126. E-mail: faresej@mail.vetmed.ufl.edu.

Abstract

Objective— To characterize biologic behavior, clinical outcome, and effect of histologic grade on prognosis for dogs with appendicular chondrosarcoma treated by amputation alone.

Study Design— Case series.

Animals— Dogs (n=25) with appendicular chondrosarcoma.

Methods— Medical records were searched to identify dogs with appendicular chondrosarcoma treated by limb amputation alone. Information recorded included signalment, anatomic location, radiographic appearance, and development of metastasis. Histopathologic diagnosis was confirmed and graded (1, 2, or 3). Survival curves were generated by the Kaplan–Meier method and the association between covariates (gender, age, weight, and tumor grade) and survival were evaluated using the univariate proportional hazards model.

Results— Histopathology slides were available for 25 dogs. Rates of pulmonary metastasis were as follows: grade 1–0%, grade 2–31%, and grade 3–50%. Overall median survival time (MST) was 979 days. Age, weight, and sex were not significantly associated with survival (P=.16; .33; and .31, respectively). Survival was significantly associated with tumor grade (P=.008), with dogs with tumor grade of 1, 2, and 3 having MSTs of 6, 2.7, and 0.9 years, respectively.

Conclusion— Canine appendicular chondrosarcoma can be treated effectively with amputation alone. Low to intermediate grade chondrosarcoma has a good prognosis, whereas high-grade tumors appear to behave aggressively.

Clinical Relevance— The overall prognosis for appendicular chondrosarcoma is better than that of appendicular osteosarcoma treated by amputation alone or in combination with chemotherapy.

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