Presented in part at the joint meeting of the 10th Annual Congress of the European Society of Veterinary Clinical Pathology (ESVCP), the 8th Biennial Congress of the International Society for Animal Clinical Pathology (ISACP), the 7th European Colloquium on Acute Phase Proteins, and the European Association of Comparative Clinical Pathology (EACCP); September 30–October 3, 2008, Barcelona, Spain.
Administration of Perioperative Penicillin Reduces Postoperative Serum Amyloid A Response in Horses Being Castrated Standing
Version of Record online: 29 APR 2010
© Copyright 2010 by The American College of Veterinary Surgeons
Volume 39, Issue 5, pages 638–643, July 2010
How to Cite
Busk, P., Jacobsen, S. and Martinussen, T. (2010), Administration of Perioperative Penicillin Reduces Postoperative Serum Amyloid A Response in Horses Being Castrated Standing. Veterinary Surgery, 39: 638–643. doi: 10.1111/j.1532-950X.2010.00704.x
- Issue online: 6 JUL 2010
- Version of Record online: 29 APR 2010
- Submitted January 2009Accepted June 2009
Objectives: To compare postoperative inflammatory responses in horses administered perioperative procaine penicillin and those not administered penicillin using acute phase protein serum amyloid A (SAA) as a marker of inflammation.
Study Design: Randomized clinical trial.
Animals: Stallions (n=50) castrated under field conditions.
Methods: SAA concentrations were determined on days 0, 3, and 8. Six horses were subsequently excluded because of elevated SAA concentrations on day 0. Of the remaining 50 horses, 26 were administered nonsteroidal anti-inflammatory drug (NSAID) therapy and 24 were administered NSAID and 25,000 U/kg procaine penicillin on day 0, 1, and 2.
Results: SAA concentrations increased significantly from preoperative levels in both groups, and on day 8 concentrations were significantly (P<.02) higher in horses administered only NSAID than in those administered procaine penicillin and NSAID. Infectious complications occurred more frequently (P<.01) in horses with preoperatively elevated SAA concentrations (the excluded horses) than in horses with normal preoperative SAA concentrations (the included horses).
Conclusions: Perioperative antimicrobial therapy reduced the postoperative SAA response, suggesting that bacteria were present in the surgical wound and contributed to inflammation after castration. Horses with elevated preoperative SAA concentrations developed infectious complications more often than horses with normal preoperative SAA concentrations.
Clinical Relevance: Administration of antimicrobials may be important in horses being castrated standing under field conditions. Increased SAA concentrations seem to be an indicator of increased surgical risk in horses and may be useful before elective surgery for planning.