The work was performed at Louisiana State University, Baton Rouge, LA in the Laboratory for Equine and Comparative Orthopedic Research.
Mesenchymal Stromal Cells: Past, Present, and Future
Article first published online: 11 JAN 2011
© Copyright 2011 by The American College of Veterinary Surgeons
Volume 40, Issue 2, pages 129–139, February 2011
How to Cite
Spencer, N. D., Gimble, J. M. and Lopez, M. J. (2011), Mesenchymal Stromal Cells: Past, Present, and Future. Veterinary Surgery, 40: 129–139. doi: 10.1111/j.1532-950X.2010.00776.x
- Issue published online: 2 FEB 2011
- Article first published online: 11 JAN 2011
- Submitted September 2009, Accepted April 2010
Adult mesenchymal stromal cells are plastic-adherent cells that are self-renewing and have the capacity to differentiate into various tissue specific lineages. Stromal cells were initially discovered over 100 years ago and substantial insight into stromal cell identification, isolation, characterization, and differentiation has been made, including efforts to elucidate the factors involved in stromal cell differentiation. Stromal cells have immune privilege and thus are attractive candidates for tissue engineering and regenerative medicine applications. Positive results from a number of recent investigations support the use of adult mesenchymal stromal cells for clinical application. This review article provides a brief overview of past, present, and future stromal cell technology.