Mesenchymal Stromal Cells: Past, Present, and Future

Authors

  • Nakia D. Spencer BS, MS,

    1. Laboratory for Equine and Comparative Orthopedic Research, Louisiana State University, School of Veterinary Medicine, Veterinary Clinical Sciences, Baton Rouge, LA
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  • Jeffrey M. Gimble MD, PhD,

    1. Stem Cell Biology Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA
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  • Mandi J. Lopez DVM, MS, PhD, Diplomate ACVS

    1. Laboratory for Equine and Comparative Orthopedic Research, Louisiana State University, School of Veterinary Medicine, Veterinary Clinical Sciences, Baton Rouge, LA
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  • The work was performed at Louisiana State University, Baton Rouge, LA in the Laboratory for Equine and Comparative Orthopedic Research.

Corresponding Author
Mandi J. Lopez, DVM, MS, PhD, Diplomate ACVS, Laboratory for Equine and Comparative Orthopedic Research, Louisiana State University, School of Veterinary Medicine, Veterinary Clinical Sciences, Skip Bertman Drive, Baton Rouge, LA 70803
E-mail: mlopez@vetmed.lsu.edu

Abstract

Adult mesenchymal stromal cells are plastic-adherent cells that are self-renewing and have the capacity to differentiate into various tissue specific lineages. Stromal cells were initially discovered over 100 years ago and substantial insight into stromal cell identification, isolation, characterization, and differentiation has been made, including efforts to elucidate the factors involved in stromal cell differentiation. Stromal cells have immune privilege and thus are attractive candidates for tissue engineering and regenerative medicine applications. Positive results from a number of recent investigations support the use of adult mesenchymal stromal cells for clinical application. This review article provides a brief overview of past, present, and future stromal cell technology.

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