This study is supported by the 2008 Surgeon-In-Training Research Grant from the American College of Veterinary Surgeons.
Original Article - Research
Use of a Dacron Shape-Memory Intravascular Coil to Achieve Slow, Progressive Occlusion of the Jugular Vein in Dogs
Article first published online: 8 SEP 2011
© Copyright 2011 by The American College of Veterinary Surgeons
Volume 40, Issue 7, pages 853–860, October 2011
How to Cite
Nanfelt, M. R., Marolf, A. J., Powers, B. E. and Monnet, E. (2011), Use of a Dacron Shape-Memory Intravascular Coil to Achieve Slow, Progressive Occlusion of the Jugular Vein in Dogs. Veterinary Surgery, 40: 853–860. doi: 10.1111/j.1532-950X.2011.00872.x
- Issue published online: 5 OCT 2011
- Article first published online: 8 SEP 2011
- Manuscript Accepted: JUL 2011
- Manuscript Received: MAY 2010
- American College of Veterinary Surgeons
To investigate the ability of shape memory Dacron polymer vascular coils to induce the complete, gradual occlusion of the canine jugular vein.
Observational pilot study.
Nine purpose-bred dogs.
Eighteen coils were deployed in nine dogs using fluoroscopic-guided percutaneous transvenous coil implantation. Individual coil formulations varied around a Dacron polymer base. Jugular vein diameter, percent vessel occlusion, and thrombus echogenicity were monitored at weekly intervals using ultrasonography. Affected jugular veins were harvested at 6 weeks post-implantation and histopathological analysis was performed to assess adventitial fibrosis, intimal layer thickening, and inflammation.
Ten coils migrated from the jugular veins to the pulmonary vasculature within 0–2 weeks following implantation. Three jugular veins achieved at least 90% occlusion at six weeks. Histopathology of these jugular veins revealed marked perivascular thickening and fibrovascular proliferation, increased infiltration of macrophages, neutrophils and lymphocytes, and abundant fibroplasia.
Complete, gradual occlusion of a jugular vein was achieved in three dogs. Significant vessel wall reaction and inflammation can induce gradual vessel occlusion when a Dacron coil remains implanted within the jugular vein. Dacron polymer coils could be a feasible treatment option for the gradual occlusion of congenital portosystemic shunts in dogs using minimally invasive, percutaneous transvenous implantation.