Presented at the Annual American College of Veterinary Surgeons Veterinary Symposium, Chicago, IL, October 17–20, 2007.
Original Article - Clinical
Outcome after Renal Transplantation in 26 Dogs
Version of Record online: 12 JAN 2012
© Copyright 2012 by The American College of Veterinary Surgeons
Volume 41, Issue 3, pages 316–327, April 2012
How to Cite
Hopper, K., Mehl, M. L., Kass, P. H., Kyles, A. and Gregory, C. R. (2012), Outcome after Renal Transplantation in 26 Dogs. Veterinary Surgery, 41: 316–327. doi: 10.1111/j.1532-950X.2011.00924.x
- Issue online: 11 APR 2012
- Version of Record online: 12 JAN 2012
- Manuscript Accepted: OCT 2011
- Manuscript Received: JUN 2011
To evaluate clinical outcome in dogs after renal transplantation and determine predictors of outcome.
Retrospective case series.
Dogs (n = 26) that had renal allograft transplantation.
Medical records (1994–2006) of 26 consecutive cases of dogs that had kidney transplantation were reviewed. History, signalment, pre- and postoperative clinicopathologic and monitoring variables, postoperative complications, immunosuppressive therapy, and survival were recorded.
Median survival was 24 days (range, 0.5 to 4014 days) with a probability of survival to 15 days of 50% and the 100-day survival probability was 36%. Cause of death was attributed to thromboembolic disease in 8 dogs, infection in 6 dogs, and rejection in 1 dog. The only factor significantly associated with an increased likelihood of death was increasing age at time of surgery (P = .024).
Canine renal transplantation in clinical patients is associated with a high morbidity and mortality and increasing recipient age has a negative association with outcome. Thromboembolic complications are a major cause of death in the immediate postoperative period and effective anticoagulation protocols may greatly improve survival in the future.