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Outcome after Renal Transplantation in 26 Dogs

Authors


  • Presented at the Annual American College of Veterinary Surgeons Veterinary Symposium, Chicago, IL, October 17–20, 2007.

Corresponding Author

Kate Hopper, BVSc, PhD, Diplomate ACVECC, Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California—Davis, Davis, CA 95616

E-mail: khopper@ucdavis.edu

Abstract

Objectives

To evaluate clinical outcome in dogs after renal transplantation and determine predictors of outcome.

Study Design

Retrospective case series.

Animals

Dogs (n = 26) that had renal allograft transplantation.

Methods

Medical records (1994–2006) of 26 consecutive cases of dogs that had kidney transplantation were reviewed. History, signalment, pre- and postoperative clinicopathologic and monitoring variables, postoperative complications, immunosuppressive therapy, and survival were recorded.

Results

Median survival was 24 days (range, 0.5 to 4014 days) with a probability of survival to 15 days of 50% and the 100-day survival probability was 36%. Cause of death was attributed to thromboembolic disease in 8 dogs, infection in 6 dogs, and rejection in 1 dog. The only factor significantly associated with an increased likelihood of death was increasing age at time of surgery (P = .024).

Conclusions

Canine renal transplantation in clinical patients is associated with a high morbidity and mortality and increasing recipient age has a negative association with outcome. Thromboembolic complications are a major cause of death in the immediate postoperative period and effective anticoagulation protocols may greatly improve survival in the future.

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