Original Article - Clinical

Safety of Autologous Bone Marrow Stromal Cell Transplantation in Dogs with Acute Spinal Cord Injury

  1. Hidetaka Nishida DVM, PhD1,2,
  2. Masanari Nakayama DVM, PhD1,
  3. Hiroshi Tanaka DVM, PhD1,
  4. Masahiko Kitamura DVM1,
  5. Shingo Hatoya DVM, PhD2,
  6. Kikuya Sugiura DVM, PhD2,
  7. Yasuji Harada DVM, PhD3,
  8. Yoshihisa Suzuki MD, PhD4,
  9. Chizuka Ide MD, PhD5,
  10. Toshio Inaba DVM, PhD2,*

Article first published online: 30 APR 2012

DOI: 10.1111/j.1532-950X.2011.00959.x

Issue

Veterinary Surgery

Veterinary Surgery

Volume 41, Issue 4, pages 437–442, May 2012

Additional Information

How to Cite

Nishida, H., Nakayama, M., Tanaka, H., Kitamura, M., Hatoya, S., Sugiura, K., Harada, Y., Suzuki, Y., Ide, C. and Inaba, T. (2012), Safety of Autologous Bone Marrow Stromal Cell Transplantation in Dogs with Acute Spinal Cord Injury. Veterinary Surgery, 41: 437–442. doi: 10.1111/j.1532-950X.2011.00959.x

Author Information

  1. 1

    Nakayama Veterinary Hospital, Nara, Japan

  2. 2

    Department of Advanced Pathobiology, Graduate School of Life and Environmental Sciences, Osaka Prefecture University, Osaka, Japan

  3. 3

    Faculty of Veterinary Medicine, Division of Veterinary Surgery, Department of Veterinary Science, Nippon Veterinary and Life Science University, Tokyo, Japan

  4. 4

    Department of Plastic and Reconstructive Surgery, Kitano Hospital, Tazuke Research Institute, Osaka, Japan

  5. 5

    Faculty of Nursing and Rehabilitation, Department of Occupational Therapy, Institute of Regeneration and Rehabilitation, Aino University, Osaka, Japan

*Corresponding Author
Toshio Inaba, DVM, PhD, Department of Advanced Pathobiology, Graduate School of Life and Environmental Sciences, Osaka Prefecture University, 1–58 Rinku Ourai Kita, Izumisano, Osaka, Japan E-mail: inaba@vet.osakafu-u.ac.jp

  1. The work was performed at Nakayama Veterinary Hospital.

Publication History

  1. Issue published online: 14 MAY 2012
  2. Article first published online: 30 APR 2012
  3. Manuscript Accepted: DEC 2011
  4. Manuscript Received: MAR 2011

Funded by

  • Scientific Research (B). Grant Number: 20380174
  • Challenging Exploratory Research. Grant Number: 22658101

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Objective

To assess the feasibility and safety of transplantation of autologous bone marrow stromal cell (BMSC) in dogs with acute spinal cord injury (SCI).

Study Design

An open-label single-arm trial.

Animals

Dogs (n = 7) with severe SCI from T6 to L5, caused by vertebral fracture and luxation.

Methods

Decompressive and stabilization surgery was performed on dogs with severe SCI caused by vertebral fracture and luxation. Autologous BMSCs were obtained from each dog's femur, cultured, and then injected into the lesion in the acute stage. Adverse events and motor and sensory function were observed for >1 year after SCI.

Results

Follow-up was 29–62 months after SCI. No complications (eg, infection, neuropathic pain, worsening of neurologic function) were observed. Two dogs walked without support, but none of the 7 dogs had any change in sensory function.

Conclusions

Autologous BMSC transplantation is feasible and safe in dogs with acute SCI. Further studies are needed to determine the efficacy of this therapy.

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