Evaluation of Osteoarthritis in Cats: Novel Information from a Pilot Study

Authors

  • Martin Guillot DV, MSc,

    1. Groupe de Recherche en Pharmacologie Animale du Québec (GREPAQ) and the Companion Animal Research Group, Faculté de Médecine Vétérinaire, Université de Montréal, Saint-Hyacinthe, Québec, Canada
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  • Maxim Moreau MSc,

    1. Groupe de Recherche en Pharmacologie Animale du Québec (GREPAQ) and the Companion Animal Research Group, Faculté de Médecine Vétérinaire, Université de Montréal, Saint-Hyacinthe, Québec, Canada
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  • Marc-André d'Anjou DMV, DACVR,

    1. Groupe de Recherche en Pharmacologie Animale du Québec (GREPAQ) and the Companion Animal Research Group, Faculté de Médecine Vétérinaire, Université de Montréal, Saint-Hyacinthe, Québec, Canada
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  • Johanne Martel-Pelletier PhD,

    1. Osteoarthritis Research Unit, Centre hospitalier de l'Université de Montréal, Hôpital Notre-Dame, Montréal, Québec, Canada
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  • Jean-Pierre Pelletier MD,

    1. Osteoarthritis Research Unit, Centre hospitalier de l'Université de Montréal, Hôpital Notre-Dame, Montréal, Québec, Canada
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  • Eric Troncy DV, PhD, DUn

    Corresponding author
    1. Osteoarthritis Research Unit, Centre hospitalier de l'Université de Montréal, Hôpital Notre-Dame, Montréal, Québec, Canada
    • Groupe de Recherche en Pharmacologie Animale du Québec (GREPAQ) and the Companion Animal Research Group, Faculté de Médecine Vétérinaire, Université de Montréal, Saint-Hyacinthe, Québec, Canada
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  • Study conducted at GREPAQ, Department of Veterinary Biomedical Sciences, Faculté de Médecine Vétérinaire, Université de Montréal, in collaboration with the CRCHUM, Université de Montréal and ArthroLab, Inc., Montréal, Québec, Canada.

  • Presented in part at the Pain and Pain Management in Non-Human Species Special Interest Group Official Satellite Symposium of the 13th World Congress on Pain, Montreal, Canada (August 29, 2010).

Corresponding Author

Eric Troncy, DV, PhD, DUn, Osteoarthritis Research Unit, Centre hospitalier de l'Université de Montréal (CRCHUM), Notre-Dame Hospital, 1560 Sherbrooke Street East, Pavillon J.-A. de Sève, Office Y-2606, Montréal (QC), H2L 4M1 Canada

E-mail: eric.troncy@umontreal.ca

Abstract

Objective

To describe structural changes associated with osteoarthritis (OA) in cats and to quantify OA-associated disability using functional evaluations.

Study Design

Cross-sectional pilot study with longitudinal data.

Animals

Normal cats (n = 2) and coxofemoral joint OA cats (n = 4) were evaluated by physical examination, radiography, and magnetic resonance imaging (MRI).

Methods

Structural changes related to OA were scored using computed radiographs (CR) and MRI. Functional evaluation consisted of podobarometric gait analyses performed using a pressure-sensitive mattress and motor activity assessments using collar-attached, accelerometer-based activity sensors.

Results

Structural scores for the coxofemoral joint OA-related lesions were lower in normal cats than OA cats for MRI (P = .07). Use of MRI allowed for whole-organ assessment of the coxofemoral joint. Pelvic limb peak vertical ground reaction force (PVF) was higher in normal cats than OA cats (P = .10). During the night, motor activity was greater in normal cats than OA cats (P = .04). PVF was positively correlated with mean motor activity (Spearman coefficient [Rho] = 0.83, P = .04) and negatively correlated with age and MRI structural score (Rho = −0.93 and −0.79, P < .01 and .06, respectively).

Conclusions

This study provides the first description of OA-related lesions in cats using MRI. Gait analysis and accelerometry should be considered as objective tools to characterize OA-associated disability, although these assessments were weakly correlated with structural changes.

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