Contract grant sponsor: University of Cuiaba; Contract grant sponsor: Cristalia Chemical Products and Pharmaceutics.
Original Article - Research
Treatment of Pythiosis in Equine Limbs Using Intravenous Regional Perfusion of Amphotericin B
Article first published online: 27 JUL 2012
© Copyright 2012 by The American College of Veterinary Surgeons
Volume 41, Issue 6, pages 759–765, August 2012
How to Cite
Dória, R. G. S., Freitas, S. H., Linardi, R. L., de Souza Mendonça, F., Arruda, L. P., Boabaid, F. M. and Valadão, C. A. A. (2012), Treatment of Pythiosis in Equine Limbs Using Intravenous Regional Perfusion of Amphotericin B. Veterinary Surgery, 41: 759–765. doi: 10.1111/j.1532-950X.2012.01019.x
- Issue published online: 6 AUG 2012
- Article first published online: 27 JUL 2012
- Manuscript Accepted: AUG 2011
- Manuscript Received: FEB 2010
- University of Cuiaba
- Cristalia Chemical Products and Pharmaceutics
To evaluate the effects of intravenous regional limb perfusion (IRLP) administration of amphotericin B in horses to treat pythiosis after surgical excision and thermocautery.
Horses (n = 12) with Pythium insidiosum infection of the distal aspect of the thoracic or pelvic limbs.
After surgical excision of granulation tissue and thermocautery, 50 mg amphotericin B was administered by IRLP through a catheter placed in a superficial vein of the affected limb next to the lesion after placing a tourniquet above the injection site. The lesions and locomotor system were evaluated before treatment and at 7, 14, 21, 28, 35, and 60 days.
Ninety-two percent of horses treated with amphotericin B had complete lesion resolution 35 or 60 days after 1 or 2 IRLP treatments, respectively. IRLP induced limb edema and pain during regional palpation in 42%, and inflammation of the injection site in 33% of horses; however these signs resolved after 14 days.
IRLP administration of amphotericin B was effective for treating pythiosis in equine limbs, resolving infection with manageable side effects.