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Adult Multipotent Stromal Cell Technology for Bone Regeneration: A Review

Authors

  • Mandi J. Lopez DVM, MS, PhD, Diplomate ACVS,

    Corresponding author
    • Laboratory for Equine and Comparative Orthopedic Research, Veterinary Clinical Sciences Department, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA
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  • Patrick R. Daigle

    1. Laboratory for Equine and Comparative Orthopedic Research, Veterinary Clinical Sciences Department, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA
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Corresponding Author

Mandi J. Lopez, DVM, MS, PhD, Diplomate ACVS, Veterinary Clinical Sciences Department, School of Veterinary Medicine, Louisiana State University, Skip Bertman Drive, Baton Rouge, LA 70803

E-mail: mlopez@vetmed.lsu.edu

Abstract

Since the discovery of bone marrow derived stromal cell osteogenesis in the 1960s, tissue engineering with adult multipotent stromal cells (MSCs) has evolved as a promising approach to restore structure and function of bone compromised by injury or disease. To date, accelerated bone formation with MSCs has been demonstrated with a variety of tissue engineering strategies. Though MSC bone tissue engineering has advanced over the last few decades, limitations to clinical translation remain. A current review of this promising field is presented with a specific focus on equine investigations.

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