Prevalence of Dysphoria after Fentanyl in Dogs Undergoing Stifle Surgery

Authors

  • Willem M. Becker DVM,

    1. Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO
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  • Khursheed R. Mama DVM, Diplomate ACVA,

    Corresponding author
    1. Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO
    • Corresponding Author

      Khursheed Mama, DVM, Diplomate ACVA, Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO 80523

      E-mail: kmama@colostate.edu

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  • Sangeeta Rao BVSc, MVSc, PhD,

    1. Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO
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  • Ross H. Palmer DVM, MS, Diplomate ACVS,

    1. Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO
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  • Erick L. Egger DVM, Diplomate ACVS

    1. Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO
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  • Funded in part by the Center for Companion Animal Studies PVM Student Grant Program at Colorado State University.

Abstract

Objective

To describe the prevalence of dysphoria after intraoperative administration of fentanyl by infusion and identify other risk factors influencing this in dogs undergoing stifle surgery.

Study Design

Prospective, randomized clinical study.

Animals

Dogs (n = 92) that had tibial plateau leveling osteotomy (TPLO) or tibial tuberosity advancement (TTA).

Methods

Dogs were anesthetized using a standardized anesthetic protocol, and randomly assigned to receive a loading dose followed by 1 of 3 infusions of fentanyl perioperatively: 2 μg/kg/h, 10 μg/kg/h, or 20 μg/kg/h. Dog characteristics and all additional medications were recorded and included as part of the statistical analysis. Dog behavior was scored before anesthesia and during recovery using a scale of 1–4 (Appendices A and B). If no improvement in behavior was seen in 3–5 minutes postextubation, dogs with a score of 3 or 4 during recovery were administered fentanyl (2 μg/kg intravenously [IV]) in the event that the behaviors associated with the higher scores were related to pain. If they did not respond favorably to the administration of additional fentanyl and wound palpation did not elicit a response, but the untoward behaviors continued, dogs were administered either a tranquilizer, sedative, or opioid antagonist, and were considered dysphoric.

Results

Of 92 dogs, 22 (23.9%) were considered dysphoric using aforementioned criteria.

Conclusions

About one-fourth of dogs enrolled in this study were dysphoric based on study criteria.

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