The Role of the Subiculum in Epilepsy and Epileptogenesis
Article first published online: 7 JUL 2005
Volume 5, Issue 4, pages 121–129, July 2005
How to Cite
Stafstrom, C. E. (2005), The Role of the Subiculum in Epilepsy and Epileptogenesis. Epilepsy Currents, 5: 121–129. doi: 10.1111/j.1535-7511.2005.00049.x
- Issue published online: 7 JUL 2005
- Article first published online: 7 JUL 2005
The subiculum is the first output structure distal to the hippocampus, abutting subfield CA1. As such, the subiculum receives afferent input from the hippocampus. Accumulating clinical and experimental evidence suggests that the subiculum plays an important role in the initiation and maintenance of epileptic discharges in temporal lobe epilepsy. This review discusses the anatomy and physiology of the subiculum and examines its participation in epilepsy and epileptogenesis.