Wrong-Way Chloride Transport: Is It a Treatable Cause of Some Intractable Seizures?
Article first published online: 4 JUL 2006
Volume 6, Issue 4, pages 124–127, July/August 2006
How to Cite
Staley, K. J. (2006), Wrong-Way Chloride Transport: Is It a Treatable Cause of Some Intractable Seizures?. Epilepsy Currents, 6: 124–127. doi: 10.1111/j.1535-7511.2006.00119.x
- Issue published online: 4 JUL 2006
- Article first published online: 4 JUL 2006
Despite decades of research and a half dozen new anticonvulsant agents, some types of seizures are as untreatable now as they were in the days of bromides. These treatment-resistant seizures suggest that some of the assumptions about anticonvulsant mechanisms may need revision. This review will focus on one of the bedrock assumptions of epileptology that the neurotransmitter GABA inhibits neuronal activity, and therefore, agents that increase GABA activity should increase inhibition and consequently decrease the abnormal neuronal activity that occurs during a seizure.