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Neurosteroids on the Epilepsy Chessboard—Keeping Seizures in Check


  • Michael A. Rogawski MD, PhD


Endogenous Neurosteroid Synthesis Modulates Seizure Frequency.  Lawrence C, Martin BS, Sun C, Williamson J, Kapur J. Ann Neurol 2010;67(5):689–693.  Inhibitory neurosteroids, molecules generated in glia from circulating steroid hormones and de novo from cholesterol, keep seizures in check in epileptic animals. They can enhance inhibitory transmission mediated by γ-aminobutyric acid receptors and have anticonvulsant action.